Healthy Clinical Trial
Official title:
The Representation of the Sensibility of the Breast on the Somatosensory Cortex Using 7 Tesla fMRI: A Pilot Study
Rationale: The representation of the breast on the somatosensory cortex has not been
precisely located. Therefore, a pilot study with healthy subjects is needed to localize the
sensibility of the breast on the somatosensory cortex with the use of a 7 Tesla fMRI.
Objective: To determine the exact localization of the representation of the sensibility of
the breast and nipple-areola complex on the somatosensory cortex. Secondly, to assess whether
there are differences in representation between individuals of the same sex and between both
sexes.
Study design: A single center pilot study carried out in the Maastricht University Medical
Center, the Netherlands.
Study population: A total of 10 female and 10 male healthy individuals will be recruited.
Intervention: Every subject will undergo a functional MRI scan with stimulators applied to
the bare breast in a fixed pattern. These stimulate the skin and sensory nerves of the breast
and nipple-areola complex in a random sequence.
Main study parameters: The hemodynamic response after stimulation of the skin of the breast
and nipple-areola complex, representing neuronal activity in that region, is measured. Within
the somatosensory cortex (S1 and S2), the temporo-spatial brain activity patterns after the
various stimulation conditions are assessed, and the representation of the breast on the
somatosensory cortex is mapped.
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