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Regulation of Intestinal and Hepatic Lipoprotein Particle Production by Blood Glucose in Humans

Healthy Clinical Trial

Official title:
Regulation of Intestinal and Hepatic Lipoprotein Particle Production by Blood Glucose in Humans

Clinical Trial Summary

The purpose of study is to examine whether raised blood glucose enhances lipid particle production independent of effects on gastric emptying and pancreatic/ gastrointestinal hormone production.

Clinical Trial Description

This study will be performed on healthy, lean, non-diabetic males and females who will participate two studies each in random order, 4 to 6 weeks apart. Study A: lipoprotein turnover with intravenous infusion of normal saline. Study B: lipoprotein turnover i.v infusion of glucose. In both studies, subjects will drink a liquid formula every hour to remain in a constant fed state and will be under conditions of pancreatic clamp (with the infusion of hormones somatostatin, insulin, glucagon, growth hormone). Subjects will be blinded with regard to the treatments. ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Single Blind (Subject), Primary Purpose: Basic Science

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02607839
Study type Interventional
Source University Health Network, Toronto
Contact
Status Completed
Phase Phase 2
Start date February 2013
Completion date September 2015
View Details
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