Healthy Clinical Trial
Official title:
Investigating the Effects of a High GI Versus a Low GI Diet on Hepatic Metabolism and Satiety Levels in Healthy Subjects
The aim of this study is to investigate the effect of a one week high versus low glycaemic index dietary intervention on hepatic glycogen and lipid levels and blood hormone levels in a two way cross overs study and to see if there is any correlation between this and satiety or appetite.
8 Healthy subject will be scanned the start and end of a 7 day high versus low glycaemic in
diet with a 4 week washout between arms. During scan days the hepatic glycogen response to a
corresponding high versus low glycaemic index test meal will be measured using 13C Magnetic
resonance spectroscopy (MRS) to explore any acute changes in metabolic response. Baseline
liver lipid levels will be measured using 1H MRS to explore any long term changes in liver
lipid levels.
Blood samples will also be obtained throughout the test day to measure for blood glucose,
insulin and blood hormone response. Satiety surveys will also be taken throughout the test
day and during the diet week.
The main hypothesis is that a one week calorie matched Glycaemic index varied diet will
result in an altered response of liver glycogen levels acutely following a meal and also
longer term hepatic liver lipid levels. A secondary hypothesis is that there will also be
associated changes in blood sugar and hormone levels and that all these changes will have an
effect on satiety levels in subjects.
;
Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Basic Science
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