Healthy Clinical Trial
Official title:
Gait, cOgnitiOn & Decline (GOOD)
The main objective of the GOOD initiative was to determine which spatio-temporal gait parameters and/or combination(s) of spatio-temporal gait parameters best differentiate between cognitively healthy individuals (CHI), patients with mild cognitive impairment (MCI) and those with mild and moderate dementia.
Gait disorders are frequent in individuals with cognitive disorders. However, the profile of
spatio-temporal gait parameters in the different cognitive status in aging (from normal
cognition to dementia) has been poorly studied. Determining this profile associated with the
severity of cognitive disorders may be helpful to understand the complex interplay between
gait and cognitive disorders and, thus, may have important implication for the diagnosis
process of patients with and without dementia. For instance, defining a motor phenotype of
the severity of cognitive disorders by using quantitative gait measurements could be used to
improve the prediction and the diagnosis of dementia.
The investigators hypothesized that, compared to CHI, people with MCI and mild dementia
could be characterized by specific phenotypes of spatio-temporal gait parameters measured
with the GAITRite® system, and that these profiles could be explained by declines in
domain-specific cognitive performance.
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Observational Model: Case Control, Time Perspective: Cross-Sectional
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