Healthy Clinical Trial
Official title:
The Effect of Topical Treatment With Combigan Compared to Timolol and Brimonidine on Pupil Diameter
In this study we will explore the combined effect of Brimonidine and Timolol 0.5% (Combigan) eye drops on pupil dilation. It is a well studied phenoma that Brimonidine and a miotic effect on the pupil, however the combined effect of alpha agonist and beta blocker has not been studied.
In this study we will explore the combined effect of Brimonidine and Timolol 0.5% (Combigan)
eye drops on pupil dilation. It is a well studied phenoma that Brimonidine and a miotic
effect on the pupil, however the combined effect of alpha agonist and beta blocker has not
been studied.
The study subjects will be examined twice, two weeks apart. On the first exam the subject
will receive Combigan eye drop to the right eye and a Brimonidine drop to the left eye. The
effect on pupil size before and 30 minutes, 60 minutes, 240 minutes, and 300 minutes after
instillation of eyedrops. On the second exam the subject will receive Timolol (0.5%) eye
drop to the right eye and a Brimonidine drop to the left eye. The effect on pupil size
before and 30 minutes, 60 minutes, 240 minutes, and 300 minutes after instillation of
eyedrops.
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Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label
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