Structural and Metabolic Determinants of Sarcopenia and the Efficacy of Concentric vs. Eccentric Exercise Training

Healthy Clinical Trial

Official title:

Structural and Metabolic Determinants of Sarcopenia and the Efficacy of Concentric vs. Eccentric Exercise Training: a Novel Temporospatial Approach

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02142855
• Other study ID #: B13032014 SoMSGEM BBSRC3
• Status: Completed
• Phase: N/A
• First received: May 16, 2014
• Last updated: October 27, 2017
• Start date: May 2014
• Est. completion date: May 2017

Study information

• Verified date: October 2017
• Source: University of Nottingham
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The first goal of this study is the follow young and older people over a period of 8 weeks to define the processes responsible for loss of muscle length and width in age-related muscle wasting (sarcopenia) and allow us to look at age-related differences in tendon. Secondly, we will assess two different exercise interventions for reversing human sarcopenia; one which involves shortening of the muscle and the other which involves lengthening, whilst also studying why these exercises work the way they do. This project will have significant implications for our understanding of the control of skeletal muscle and tendon size in humans, particularly in relation to sarcopenia and the surrounding health issues.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 60
• Est. completion date: May 2017
• Est. primary completion date: May 2017
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 75 Years

Eligibility

Inclusion Criteria:

• Healthy male volunteers

• Body mass index 18-30 kg/m2

• Aged 18-35 and 65-75 years

Exclusion Criteria:

• Participation in a formal exercise regime,

• A BMI < 18 or > 30 kg/m2,

• Active cardiovascular disease,

• Taking beta-adrenergic blocking agents, statins or non-steroidal anti-inflammatory drugs,

• Cerebrovascular disease,

• Respiratory disease,

• Metabolic disease,

• Active inflammatory bowel or renal disease,

• Malignancy,

• Recent steroid treatment (within 6 months) or hormone replacement therapy,

• Clotting dysfunction,

• Musculoskeletal or neurological disorders,

• Family history of early (<55y) death from cardiovascular disease

Related Conditions & MeSH terms

• Healthy
• Sarcopenia

Intervention

Behavioral:
• Concentric Exercise Training
8 weeks concentric exercise training, 3 x per week, 60% 1-RM; 4 x 12-15 repetitions, 2 min rest between sets
• Eccentric Exercise Training
8 weeks eccentric exercise training, 3 x per week, 60% 1-RM; 4 x 12-15 repetitions, 2 min rest between sets

Locations

Country	Name	City	State
United Kingdom	University of Nottingham	Derby	Derbyshire

Sponsors (2)

Lead Sponsor	Collaborator
University of Nottingham	Biotechnology and Biological Sciences Research Council

Country where clinical trial is conducted

United Kingdom, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Muscle function	Muscle strength, force and power in young and older individuals and in response to 8 weeks concentric or eccentric exercise training	0 - 8 weeks
Primary	Muscle protein synthesis	Comparison of muscle protein synthesis using D2O in young and older individuals and in response to 8 weeks concentric or eccentric exercise training	0 - 8 weeks
Secondary	Tendon protein synthesis	Comparison of tendon protein synthesis in young and older individuals and in response to 8 weeks concentric or eccentric exercise training	0 - 8 weeks