Healthy Clinical Trial
Official title:
Folic Acid Handling by the Human Gut: Implications for Food Fortification and Supplementation
The aim of this study is to test the assumption that, in humans, folic acid, a dietary supplement is biotransformed (reduced and methylated) to the natural circulating plasma folate 6S-5Methyltetrahydrofolic acid (5-MTHF) in the intestinal mucosa.
Current thinking, based mainly on rodent studies, is that physiological doses of folic acid
(pteroylmonoglutamic acid), like dietary vitamin folates, are biotransformed in the
intestinal mucosa and transferred to the portal vein as the natural circulating plasma
folate, 5-methyltetrahydrofolic acid (5-MTHF), before entering the liver and the wider
systemic blood supply.
Study design:Open labelled study that samples portal and peripheral veins for labelled
folate concentrations following oral ingestion with physiological doses of dietary
supplements stable-isotope-labelled folic acid, or, the reduced folate,
5-formyltetrahydrofolic acid (5-FormylTHF). The study was performed in subjects with a
Transjugular Intrahepatic Porto Systemic Shunt (TIPSS) in situ at the time of a routine
annual patency check to allow blood samples to be taken from the portal vein. The aim of
this study is to test the assumption that, in humans, folic acid is biotransformed (reduced
and methylated) to 5-MTHF in the intestinal mucosa.
;
Endpoint Classification: Pharmacokinetics Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science
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