Metabolic and Physiological Stress During Skiing.

Healthy Clinical Trial

Official title:

Metabolic and Physiological Stress During Alpine Skiing, Cross-country Skiing and Indoor Training in Untrained and Trained Persons.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02082106
• Other study ID #: UISM-2014-MET-SKI
• Status: Completed
• Phase: N/A
• First received: February 11, 2014
• Last updated: April 28, 2015
• Start date: January 2014
• Est. completion date: May 2014

Study information

• Verified date: April 2015
• Source: Paracelsus Medical University
• Contact: n/a
• Is FDA regulated: No
• Health authority: Austria: Ethikkommission
• Study type: Observational

Clinical Trial Summary

Problem description In industrialized countries there is a rapid increase in the number of senior citizens. In Austria more than 50% of the population is overweight, with highest prevalence in the age group from 60 to 74 yrs and the WHO lists physical inactivity as one of the main behavioral risk factors of cardiovascular diseases.

Especially in winter months, activity related energy expenditure was 40% and 31% lower in the US and Canada, respectively. In addition, in an Austrian study the winter season was associated with higher blood pressure, total cholesterol and body mass index, giving an increasing risk of chronic coronary disease by 6.8% in men and 3.6% in women.

Therefore, the development of intervention programs that overcome the winter physical activity deficit and be feasible also for elderly should be goal of future research. Alpine skiing (AS) and cross country skiing (XCS) have a long standing tradition in Austria and could potentially fill the winter physical activity gap. The Salzburg Skiing for the Elderly Study (SASES) has found AS to be a save and feasible possibility to improve the health of the aged population in many parameters. XCS as a competitive sport is already well explored but there are hardly any studies about its effects in the normal or elderly population. Unfortunately knowledge about the differences between AS and XCS in the physiological adaptation processes in the elderly population is also lacking.

Aims and hypotheses of the pre-study In order to standardize training interventions, the present pre-study aims at comparing physiological and metabolic parameters between AS, XCS and IT. Therefore, the results of the pre-study serve as determinants for the training parameters of the above mentioned main study.

We postulate that, based on the results of the present study, it is possible to set up comparable isocaloric training sessions for AS, XCS and IT for elderly and unfit persons.

Furthermore, we assume that elderly and unfit subjects are able to perform a full spectrum of intensities and techniques necessary to set appropriate stimuli for isocaloric comparison.

We hypothesize arterial stiffness indices and circulating microRNA (miRNA) patterns to change due to one bout of physical activity of AS, XCS, and IT with variations depending on the kind of sport.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 21
• Est. completion date: May 2014
• Est. primary completion date: May 2014
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 30 Years and older

Eligibility

Inclusion Criteria:

• written informed consent

• male or female

• age: 30+ years

• inconspicuous ECG

• Non-smoker for at least one year

• proper skills in alpine skiing and cross-country skiing

Exclusion Criteria:

• Participation in other clinical trials at the same time or within the previous 6 months

• Tiffeneau-Pinelli index: Forced Expiratory Volume in first second (FEV1) / Forced Vital Capacity (FVC) <60% with/without symptoms (coughing, sputum) or other evidence of a pulmonary disease

• medical condition which conflicts with participation in training

• Intake of anticoagulants

• Alcohol or drug abuse

• Severe obesity: BMI >40

Study Design

Observational Model: Cohort, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

• Healthy

Intervention

Other:
• Alpine skiing

• cross country skiing

• Indoor training (cycling)

Locations

Country	Name	City	State
Austria	University Institute of Sports Medicine, Prevention and Rehabilitation	Salzburg

Sponsors (1)

Lead Sponsor	Collaborator
Paracelsus Medical University

Country where clinical trial is conducted

Austria, 

References & Publications (4)

Finkenzeller T, Müller E, Würth S, Amesberger G. Does a skiing intervention influence the psycho-social characteristics of the elderly? Scand J Med Sci Sports. 2011 Aug;21 Suppl 1:69-75. doi: 10.1111/j.1600-0838.2011.01344.x. — View Citation

Müller E, Gimpl M, Kirchner S, Kröll J, Jahnel R, Niebauer J, Niederseer D, Scheiber P. Salzburg Skiing for the Elderly Study: influence of alpine skiing on aerobic capacity, strength, power, and balance. Scand J Med Sci Sports. 2011 Aug;21 Suppl 1:9-22. doi: 10.1111/j.1600-0838.2011.01337.x. — View Citation

Müller E, Gimpl M, Poetzelsberger B, Finkenzeller T, Scheiber P. Salzburg Skiing for the Elderly Study: study design and intervention--health benefit of alpine skiing for elderly. Scand J Med Sci Sports. 2011 Aug;21 Suppl 1:1-8. doi: 10.1111/j.1600-0838.2011.01336.x. — View Citation

Niederseer D, Ledl-Kurkowski E, Kvita K, Patsch W, Dela F, Mueller E, Niebauer J. Salzburg Skiing for the Elderly Study: changes in cardiovascular risk factors through skiing in the elderly. Scand J Med Sci Sports. 2011 Aug;21 Suppl 1:47-55. doi: 10.1111/j.1600-0838.2011.01341.x. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	RNA	Total RNA will be isolated from stored plasma and blood cell samples. All samples will be screened for influence of acute exercise (before/after physical examination and indoor training).	12 weeks	No
Other	Nitric oxide (NO)	NO will be quantified out of stored blood samples and serves as a possible surrogate parameter of pulse wave analysis.	12 weeks	No
Other	Metabolic screening	Metabolic parameters (e.g. glucose, lactate) will be quantified out of stored blood samples: These parameters serve as determinants of the different exercises.	12 weeks	No
Primary	Oxygen consumption (VO2)	VO2 will be measured during during physical examination, indoor training, Alpine Skiing, and Cross Country Skiing. VO2 will be transformed into metabolic equivalents to calculate isocaloric training parameters for the different kind of sport.	12 weeks	No
Secondary	Pulse wave analysis (PWA)	PWA will be measured before/after physical examination, indoor training, Alpine Skiing, and Cross Country Skiing. PWA will be done by oscillometric measurement to calculate influence of acute exercise and training status on several pulse wave parameters.	12 weeks	No

External Links

•   Research Institute of Molecular Sport and Rehabilitation Medicine
•   University Institute of Sports Medicine, Prevention and Rehabilitation