Healthy Clinical Trial
Minimal data are available on protein requirements throughout the lifespan. Currently
available recommendations are based on nitrogen balance data. The limitations of the nitrogen
balance method have been well described. Importantly, nitrogen balanced underestimates
requirements.
The current dietary reference intake (DRI) requirement for healthy adult males is based on
the reanalysis of the nitrogen balance date from Young and Scrimshaw. This data was
reanalyzed statistically by Rand et al. and he concluded that the protein requirement of
healthy adults was 0.65 and 0.83 (mean and RDA) g/kg/day of good quality protein. Using IAAO,
our group estimated the protein requirement of young men (mean age 27 years) to be 0.93 and
1.2 g/kg/day (mean and RDA).
Currently there are no studies on protein requirement in the elderly. In a recent nutrition
survey conducted by national health and nutrition examination survey (NHANES), the authors
concluded that adults between the ages of 51 - 70 years old consumed an average on 1.0
g/kg/day (ideal body weight) of protein which represents about 15 % of calories. Depending on
the calculations used for ideal body weight some older adults could be getting higher or
lower than requirement. There is no scientifically derived protein estimate for older adults.
Therefore there is a need to measurer protein requirement in that population.
The goal of this study therefore is to measure the protein requirement of male elderly
subjects > 75 years using the indicator amino acid oxidation (IAAO) technique.
Hypothesis:
The investigators hypothesize the protein requirement in elderly male subjects will be lower
(0.85-1.05 g/kg/day) than that established in young healthy males ( 0.93 - 1.2g/kg/day).
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT06052553 -
A Study of TopSpin360 Training Device
|
N/A | |
| Completed |
NCT05511077 -
Biomarkers of Oat Product Intake: The BiOAT Marker Study
|
N/A | |
| Recruiting |
NCT04632485 -
Early Detection of Vascular Dysfunction Using Biomarkers From Lagrangian Carotid Strain Imaging
|
||
| Completed |
NCT05931237 -
Cranberry Flavan-3-ols Consumption and Gut Microbiota in Healthy Adults
|
N/A | |
| Terminated |
NCT04556032 -
Effects of Ergothioneine on Cognition, Mood, and Sleep in Healthy Adult Men and Women
|
N/A | |
| Completed |
NCT04527718 -
Study of the Safety, Tolerability and Pharmacokinetics of 611 in Adult Healthy Volunteers
|
Phase 1 | |
| Completed |
NCT04065295 -
A Study to Test How Well Healthy Men Tolerate Different Doses of BI 1356225
|
Phase 1 | |
| Completed |
NCT04107441 -
AX-8 Drug Safety, Tolerability and Plasma Levels in Healthy Subjects
|
Phase 1 | |
| Completed |
NCT04998695 -
Health Effects of Consuming Olive Pomace Oil
|
N/A | |
| Completed |
NCT01442831 -
Evaluate the Absorption, Metabolism, And Excretion Of Orally Administered [14C] TR 701 In Healthy Adult Male Subjects
|
Phase 1 | |
| Terminated |
NCT05934942 -
A Study in Healthy Women to Test Whether BI 1358894 Influences the Amount of a Contraceptive in the Blood
|
Phase 1 | |
| Recruiting |
NCT05525845 -
Studying the Hedonic and Homeostatic Regulation of Food Intake Using Functional MRI
|
N/A | |
| Completed |
NCT05515328 -
A Study in Healthy Men to Test How BI 685509 is Processed in the Body
|
Phase 1 | |
| Completed |
NCT05030857 -
Drug-drug Interaction and Food-effect Study With GLPG4716 and Midazolam in Healthy Subjects
|
Phase 1 | |
| Completed |
NCT04967157 -
Cognitive Effects of Citicoline on Attention in Healthy Men and Women
|
N/A | |
| Recruiting |
NCT04714294 -
Evaluate the Safety, Tolerability and Pharmacokinetics Characteristics of HPP737 in Healthy Volunteers
|
Phase 1 | |
| Recruiting |
NCT04494269 -
A Study to Evaluate Pharmacokinetics and Safety of Tegoprazan in Subjects With Hepatic Impairment and Healthy Controls
|
Phase 1 | |
| Completed |
NCT04539756 -
Writing Activities and Emotions
|
N/A | |
| Recruiting |
NCT04098510 -
Concentration of MitoQ in Human Skeletal Muscle
|
N/A | |
| Completed |
NCT03308110 -
Bioavailability and Food Effect Study of Two Formulations of PF-06650833
|
Phase 1 |