Influence of Trigger Threshold on Controlled Twitch Mouth Pressure

Healthy Clinical Trial

Official title:

Influence of Trigger Threshold on Controlled Twitch Mouth Pressure

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01891942
• Other study ID #: GIRD-566
• Secondary ID: GIRD-566
• Status: Completed
• Phase: N/A
• First received: June 26, 2013
• Last updated: July 2, 2013
• Start date: June 2012
• Est. completion date: June 2013

Study information

• Verified date: June 2013
• Source: Guangzhou Institute of Respiratory Disease
• Contact: n/a
• Is FDA regulated: No
• Health authority: China: Ethics Committee
• Study type: Interventional

Clinical Trial Summary

The inspiratory pressure trigger is essential when assessing the twitch mouth pressure (Tw Pmo) for avoiding glottic closure. However, the difference in inspiratory pressure trigger threshold may influence the values of Tw Pmo. We sought to determine the trigger threshold for healthy subjects and COPD patients.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 30
• Est. completion date: June 2013
• Est. primary completion date: June 2013
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 80 Years

Eligibility

Inclusion Criteria:

1. Clinical diagnosis of COPD

2. Stable with no episodes of exacerbation within the previous 2 months

3. Do not currently being treated with oral corticosteroids

Exclusion Criteria:

1. Not stable within the previous 2 months.

2. Patients with COPD were currently being treated with oral corticosteroids

Study Design

Allocation: Randomized, Endpoint Classification: Safety Study, Intervention Model: Factorial Assignment, Masking: Single Blind (Subject), Primary Purpose: Diagnostic

Related Conditions & MeSH terms

• COPD
• Healthy

Intervention

Procedure:
• twitch by magstim

Locations

Country	Name	City	State
China	Guangzhou Institute Respiratory Disease	Guangzhou	Guangdong

Sponsors (1)

Lead Sponsor	Collaborator
Guangzhou Institute of Respiratory Disease

Country where clinical trial is conducted

China, 

References & Publications (2)

Hua DM, Liang YH, Xie YK, Liu Q, Zheng ZG, Chen RC, Zhong NS. Use of twitch mouth pressure to assess diaphragm strength in patients with chronic obstructive pulmonary disease. Respir Physiol Neurobiol. 2013 Jul 1;187(3):211-6. doi: 10.1016/j.resp.2013.04. — View Citation

Walker DJ, Ertl T, Walterspacher S, Schlager D, Roecker K, Windisch W, Kabitz HJ. Respiratory muscle function during a six-week period of normocapnic hyperpnoea training. Respir Physiol Neurobiol. 2013 Aug 15;188(2):208-13. doi: 10.1016/j.resp.2013.05.005 — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Twitch mouth pressure		2 weeks	Yes
Secondary	Twitch oesophageal pressure		2 weeks	Yes