Healthy Clinical Trial
The blood hormone Erythropoietin (Epo) is not only produced by the kidneys but also by the
brain, especially under hypoxic conditions. It has been shown in animal studies and human
studies that Epo has neuroprotective properties. Furthermore, there is scientific evidence
for central modulatory effects of Epo in the brain but high dose of Epo is needed to
overcome the blood brain barrier. In a double blind placebo controlled crossover study we
will investigate the effects of a single high dose of Epo on cognitive function and exercise
capacity in healthy subjects. The subjects will receive a single high dose of Epo (60.000
IU) and will perform a computerized cognitive test battery, a breathing test, a maximal
exercise capacity test (VO2max), and a time trial (TT) 24 hours after the treatment. The
primary outcome of the study will be the cognitive function.
- Trial with medicinal product
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Basic Science
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