Healthy Clinical Trial
Official title:
Susceptibility Changes Among Oral Microorganisms Following Single Dose Antibiotic Prophylaxis
The hypothesis of the present study is that quantitative and qualitative oral microflora alterations and changes in antibiotic susceptibility among oral commensal microflora will occur following a single dose administration of amoxicillin.
A total of 33 healthy volunteers, 16 males and 17 females, will be included. Written
informed consent will be obtained from all participants.
Subjects will be excluded if they have taken antibiotics within the previous three months,
are pregnant, breast-feeding or allergic against penicillin.
The participants will be given a single dose of 2 g amoxicillin. Saliva samples will be
collected before administration of antibiotics (day 1) and on day 2, 5, 10, 17 and 24.
Un-stimulated saliva will be accumulated in a plastic container. Concentration of
amoxicillin in saliva will be measured on day 1, 2 and 5. Samples will be used for the
determination of antibiotic concentration. Analyses of the sensitivities to amoxicillin and
some other clinically relevant antibiotic compounds will also be performed.
;
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Prevention
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