Effects of Low-level Laser Therapy on Global Gene Expression of Young Males Submitted to Physical Strength Training

Healthy Clinical Trial

Official title:

Effects of Low-level Laser Therapy on Global Gene Expression of Young Males Submitted to Physical Strength Training

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01784432
• Other study ID #: CAAE: 0150.0.135.000-10
• Status: Completed
• Phase: N/A
• First received: September 15, 2012
• Last updated: February 3, 2013
• Start date: January 2011
• Est. completion date: September 2012

Study information

• Verified date: February 2013
• Source: Universidade Federal de Sao Carlos
• Contact: n/a
• Is FDA regulated: No
• Health authority: Brazil: National Committee of Ethics in Research
• Study type: Interventional

Clinical Trial Summary

Muscle performance is largely influenced by modulations in gene expressions of muscle tissue. In this context, low-level laser therapy has been used to improve muscle performance in experimental models and human researches. Thereby, the investigators examined modulations on global gene expression of muscle tissue influenced by exercise associated to low-level laser therapy.

Description:

This study assessed muscle performance in isokinetic dynamometry and leg press device; global gene expression of muscle tissue by microarray analysis

Recruitment information / eligibility

• Status: Completed
• Enrollment: 30
• Est. completion date: September 2012
• Est. primary completion date: January 2012
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 28 Years

Eligibility

Inclusion Criteria:

• healthy males aged between 18 and 28 years;

• body mass index (BMI) equal to or less than 26 kg/m2;

• moderated pattern of physical activity

Exclusion Criteria:

• previous injury to the femoral quadriceps or hamstring muscles (within 6 months prior to study),

• osseous or articular disorder in the lower limbs,

• cardiovascular system disorders,

• systemic disease, and

• taking prescription medicines or using dietary supplements such as muscle mass builders

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Factorial Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Healthy

Intervention

Device:
• Low-level laser therapy and training

Other:
• Training

Locations

Country	Name	City	State
Brazil	Federal University of São Carlos	São Carlos	São Paulo

Sponsors (5)

Lead Sponsor	Collaborator
Universidade Federal de Sao Carlos	Centro de Pequisas de Ótica e Fotônica, Faculdade de Medicina de Ribeirão Preto (FMRP-USP), Fundação de Amparo à Pesquisa do Estado de São Paulo, Fundação Hemocentro de Ribeirão Preto

Country where clinical trial is conducted

Brazil, 

References & Publications (2)

Ferraresi C, de Brito Oliveira T, de Oliveira Zafalon L, de Menezes Reiff RB, Baldissera V, de Andrade Perez SE, Matheucci Júnior E, Parizotto NA. Effects of low level laser therapy (808 nm) on physical strength training in humans. Lasers Med Sci. 2011 May;26(3):349-58. doi: 10.1007/s10103-010-0855-0. Epub 2010 Nov 18. — View Citation

Vieira WH, Ferraresi C, Perez SE, Baldissera V, Parizotto NA. Effects of low-level laser therapy (808 nm) on isokinetic muscle performance of young women submitted to endurance training: a randomized controlled clinical trial. Lasers Med Sci. 2012 Mar;27(2):497-504. doi: 10.1007/s10103-011-0984-0. Epub 2011 Aug 26. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Immunohistochemical analysis	Immunohistochemical analysis to quantify morphology and cells of muscle tissue as satellite cells.	12 weeks	No
Primary	Global gene expression by microarray analysis		12 weeks	No
Secondary	Muscle performance in leg press device		12 weeks	No
Secondary	Muscle performance in isokinetic dynamometer		12 weeks	No

External Links

•   Link