Effects of Phototherapy by Low-level Light-emitting Diode Therapy (LEDT) on Clinical, Biochemical, Biomechanical, Histologic and Genetic Responses of Muscle Performance of Young Males Submitted to Physical Strength Training

Healthy Clinical Trial

Official title:

Effects of Phototherapy by Low-level Light-emitting Diode Therapy (LEDT) on Clinical, Biochemical, Biomechanical, Histologic and Genetic Responses of Muscle Performance of Young Males Submitted to Physical Strength Training

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01770938
• Other study ID #: CAAE: 0326.0.135.000-11
• Status: Completed
• Phase: N/A
• First received: September 15, 2012
• Last updated: September 19, 2014
• Start date: May 2012
• Est. completion date: September 2014

Study information

• Verified date: September 2014
• Source: Universidade Federal de Sao Carlos
• Contact: n/a
• Is FDA regulated: No
• Health authority: Brazil: National Committee of Ethics in Research
• Study type: Interventional

Clinical Trial Summary

Muscle performance is largely influenced by modulations in gene expressions of muscle tissue. In this context, light-emitting diode therapy (LEDT) has been used to improve muscle performance in experimental models and human researches. Thereby, the investigators examined modulations in gene expression of muscle tissue as well as biochemical, biomechanic and histologic adaptations influenced by exercise associated to LEDT.

Description:

This study assessed muscle performance in isokinetic dynamometry and led press device, gene expression by RT-PCR, lactate, creatine kinase and morphology of muscle tissue by immunohistochemical analysis

Recruitment information / eligibility

• Status: Completed
• Enrollment: 32
• Est. completion date: September 2014
• Est. primary completion date: July 2012
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 28 Years

Eligibility

Inclusion Criteria:

• healthy males aged between 18 and 28 years with a body mass index (BMI) equal to or less than 26 kg/m2,

• moderated pattern of physical activity

Exclusion Criteria:

• previous injury to the femoral quadriceps or hamstring muscles (within 6 months prior to study),

• osseous or articular disorder in the lower limbs,

• cardiovascular system disorders,

• systemic disease, and

• taking prescription medicines or using dietary supplements such as muscle mass builders.

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Related Conditions & MeSH terms

• Healthy

Intervention

Device:
• Effective light-emitting diode therapy

• Placebo light-emitting diode therapy

Locations

Country	Name	City	State
Brazil	Federal University of São Carlos	São Carlos	São Paulo

Sponsors (3)

Lead Sponsor	Collaborator
Universidade Federal de Sao Carlos	Centro de Pequisas de Ótica e Fotônica, Fundação de Amparo à Pesquisa do Estado de São Paulo

Country where clinical trial is conducted

Brazil, 

References & Publications (2)

Ferraresi C, de Brito Oliveira T, de Oliveira Zafalon L, de Menezes Reiff RB, Baldissera V, de Andrade Perez SE, Matheucci Júnior E, Parizotto NA. Effects of low level laser therapy (808 nm) on physical strength training in humans. Lasers Med Sci. 2011 May;26(3):349-58. doi: 10.1007/s10103-010-0855-0. Epub 2010 Nov 18. — View Citation

Vieira WH, Ferraresi C, Perez SE, Baldissera V, Parizotto NA. Effects of low-level laser therapy (808 nm) on isokinetic muscle performance of young women submitted to endurance training: a randomized controlled clinical trial. Lasers Med Sci. 2012 Mar;27(2):497-504. doi: 10.1007/s10103-011-0984-0. Epub 2011 Aug 26. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Immunohistochemical analysis	Immunohistochemical analysis to quantify morphology and cells of muscle tissue as satellite cells.	12 weeks	No
Primary	Modulations on muscle gene expression by RT-PCR		12 weeks	No
Secondary	Muscle performance in leg press device		12 weeks	No
Secondary	Muscle performance in leg extension device		12 weeks	No
Secondary	Muscle performance in isokinetic dynamometer		12 weeks	No
Secondary	Gene expression	Gene expression of muscle tissue by RT-PCR	12 weeks	No

External Links

•   Link