Healthy Clinical Trial
Official title:
Effects of Test Meal Volume and Energy Density on Gastric Volumes and Satiety Assessed by MRI
The GI MRI Research group at the University of Nottingham has been developing new, non-invasive magnetic resonance imaging (MRI) techniques to image the gastrointestinal tract. In collaboration with food manufacturer Unilever, the investigators want to image the abdomen of healthy volunteers after consumption of test meals of varying volume and energy density to determine levels of gastric distension and investigate possible correlations of this with the subjects' sense of satiety.
The tone of the proximal stomach decreases on meal intake through a process of gastric
accommodation, aimed at increasing the capacity of the stomach. An increased gastric volume
progressively distends the stomach, and this distension has been shown to have an inverse
relationship on appetite. The link is assumed to be based on activation of mechanoreceptors
lying in the walls of the stomach. On activation, vagal discharges are triggered, leading to
activation of hypothalamic neurons and regulation of feelings of satiety. Gasrtric emptying
is also regulated by duodenal feedback mechanisms triggered by the arrival and amount of
nutrients.
Based on current knowledge, a high volume test meal would be expected to produce more
gastric distension and satiety over a low volume test meal, and a low energy density food
would be expected to empty from the stomach faster than a high energy density food. Going on
this premise, study test meal 2 would be expected to empty faster than study test meal 1.
These phenomena will be investigated using non invasive Magnetic Resonance Imaging (MRI)
methods. MRI can measure gastric volumes serially and non-invasively with high spatial
resolution. Ultimately, the findings from this study will provide novel insights on
mechanisms of gastric distension and satiety.
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Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Basic Science
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