Healthy Clinical Trial
Official title:
Ex Vivo LPS Stimulation in Healthy and Compromised Subjects
Ex vivo LPS stimulation of whole blood will be a good alternative challenge to induce an
inflammatory response and examine differences in the inflammatory response between healthy
and compromised subjects.
The purpose of the current study is to examine the inflammatory response in a younger
population (35-45 yrs old) to see whether in this population also differences in the ex vivo
LPS induced cytokine response exists between healthy and compromised subjects, as is seen in
elderly subjects. Overweight subjects showing a state of disturbed blood glucose control
will be included as subjects with compromised health and compared to healthy lean subjects
with the same age (shifting from healthy towards unhealthy, not diseased).
Hypothesis Ex vivo LPS stimulation of whole blood will induce a measurable inflammatory
cytokine response in a healthy population that is different from a response of the
compromised population. The investigators will include subjects aged 35-45 years that differ
in health characteristics, especially blood HbA1c, fat% and waist circumference.
n/a
Observational Model: Case Control
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