Zinc Absorption From Zinc Citrate, Zinc Gluconate and Zinc Oxide

Healthy Clinical Trial

Official title:

Zinc Absorption From Zinc Supplements Comparing Zinc Citrate to Zinc Gluconate and Zinc Oxide in Young Adults

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01576627
• Other study ID #: HNL/CTC11-12
• Status: Completed
• Phase: N/A
• First received: April 4, 2012
• Last updated: January 3, 2013
• Start date: March 2012
• Est. completion date: November 2012

Study information

• Verified date: January 2013
• Source: Swiss Federal Institute of Technology
• Contact: n/a
• Is FDA regulated: No
• Health authority: Switzerland: Ethikkommission
• Study type: Interventional

Clinical Trial Summary

The goal of this trial is to evaluate zinc citrate, a zinc compound with promising sensory properties and a high zinc content, as an alternative zinc compound to be used for supplementation or food fortification. The bioavailability of zinc citrate given as a supplement to young Swiss adults will be assessed and compared to the bioavailability of the commonly used zinc compounds zinc gluconate and zinc oxide.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 15
• Est. completion date: November 2012
• Est. primary completion date: May 2012
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years to 45 Years

Eligibility

Inclusion Criteria:

• Male or female of 18 to 45 years old

• Body Mass Index in the range of 19 to 25

• No mineral and vitamin supplements two weeks prior to the study and during the whole duration of the study

Exclusion Criteria:

• Any metabolic, gastrointestinal or chronic disease (according to the subjects own statement)

• Long-term medication during the whole study (except for contraceptives)

• Vegans

• Pregnancy

• Lactation

• Intention to become pregnant during the course of the study

• Lack of safe contraception

• Consumption of mineral and vitamin supplements within 2 weeks prior to 1st test supplement administration

• Earlier participation in any nutrition study using Zn stable isotopes as well as participation in any other clinical study within the last 30 days and during this study

Study Design

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)

Related Conditions & MeSH terms

• Healthy

Intervention

Dietary Supplement:
• zinc citrate
10 mg of zinc as either zinc citrate
• Zinc Gluconate
10 mg of zinc as either zinc gluconate
• Zinc oxide
10 mg of zinc as either zinc oxide

Locations

Country	Name	City	State
Switzerland	ETH Zurich	Zurich

Sponsors (2)

Lead Sponsor	Collaborator
Prof. Michael B. Zimmermann	University of Zurich

Country where clinical trial is conducted

Switzerland, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Fractional absorption of zinc	Fractional absorption of zinc is estimated by using the double isotope tracer ratio technique by administering 67Zn as oral and 70Zn as intravenous stable isotopes.The urinary enrichment with both isotopes is measured in a spot urine sample by inductively coupled plasma mass spectrometry.	61 days	No