Healthy Clinical Trial
Official title:
Assessment of the Muscle Protein Fractional Synthesis Rate Induced by Repeated Administrations of GLPG0492 to Healthy Male Subjects and Assessment of the Safety, Tolerability and Pharmacokinetics of Repeated Administrations of GLPG0492 to Healthy Postmenopausal Women.
GLPG0492 is a selective androgen receptor modulator: the compound should help protect
against (or help restore) muscle loss in case of immobilization (e.g. after orthopedic
surgery) or due to aging (androgenic effect), but without anabolic effects (e.g. effect on
testosterone). In the first part of the current study it will be tested whether GLPG0492
given orally to healthy male volunteers increases the protein synthesis in muscle, as
measured by the uptake into the muscle of intravenously infused phenylalanine.
In the second part of the study, the effect of the compound on the "hormone household" in
healthy, postmenopausal women will be assessed.
n/a
Allocation: Randomized, Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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