Healthy Clinical Trial
Official title:
Evaluation of Circulating Osteogenic Factors in Trauma Patients (BMP-9)
Bone fractures in traumatic brain-injured and spinal cord-injured patients often heal faster
than in other patients. However, such patients are also occasionally prone to bone formation
in soft tissues such as muscle. This process is called heterotopic ossification and tends to
occur around joints. Patients with heterotopic ossification often suffer from complications
such nerve compression, ankylosis, chronic pain, osteoporosis, and infections. Loss of
movement can also interfere with function and the quality of life of patients already
experiencing difficulties associated with their trauma. Positioning, transfers, and hygiene
become difficult and even impossible, which worsens the loss of autonomy.
Previous research has suggested that an osteoinductive factor (which has the capacity to
induce the formation of bone) may be released into the bloodstream following a head or spinal
cord injury. The investigators laboratory has shown that a growth factor called BMP-9, when
injected into a damaged mouse muscle, has the ability to cause strong ossification in damaged
muscle. The investigators would like to find out whether the levels of BMP-9 and/or its
receptor (which is called ALK1) increase after traumatic brain and spinal cord injuries that
occur at the same time as serious orthopaedic traumas.
The main goal of the investigators study is thus to determine whether BMP-9 levels increase
in the serum of trauma patients.
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