Healthy Clinical Trial
Official title:
Acute Effects of Sn-1 and Sn-3 Palmitic Acid-rich or Stearic Acid-rich Fats on Postprandial Lipemia, Haemostatic and Inflammatory Markers, Gut Hormone Concentrations, Satiety, and Insulinemic Response in Human Volunteers
To determine the effect of degree of fat saturation on postprandial lipemia, haemostatic and
inflammatory markers, gut hormone concentrations, satiety perceptions, and insulinemic
responses in healthy adult subjects.
Study hypothesis: The degree of fat saturation does not affect postprandial lipemia,
haemostatic and inflammatory markers, gut hormone concentrations, insulinemic or satiety
responses in health adult subjects.
The experimental are comprise of 50g fat, 14g protein and 84g carbohydrate. Each of the test
fat [palm mid fraction (PMF), shea butter (SB) and high oleic sunflower oil (HOSF)] will be
compared which will be in a form of experimental meals (muffin).
33 volunteers receives 3 experimental meals (muffins) in a random order, 2 week apart, over
a 6-week period. They will be randomized, blinded and will undergo a 3x3 arms crossover. The
first 15-ml ("0" min) fasting venous blood samples is obtained. Immediately thereafter, the
subject consumes the test meal plus a glass of water within 15 minutes. The time sequence is
started mid-way of consuming the test meal.
At 30 min, 60 min, 90, 120 min (2 hr), 150 min and 180 min (3 hr), 210 min, and 240 min (4
hr), 15-ml each of blood is collected (via a vascular catheter inserted earlier in the
subjects hand/arm).
;
Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Investigator, Outcomes Assessor), Primary Purpose: Basic Science
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