Healthy Clinical Trial
Official title:
The Role of the Inferior Frontal Gyrus in Long-Term Auditory Memory a rTMS Study
Verified date | October 30, 2015 |
Source | National Institutes of Health Clinical Center (CC) |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
Background:
- Studies have shown that animals such as monkeys and dogs have excellent sight and touch
memory but perform poorly on sound memory tasks. Human brains have certain areas that are
important for speaking and understanding language. These areas may be involved in sound and
spoken word memory. Researchers want to study these areas of the brain to find out if the
memory for sounds requires brain structures that are usually associated with language
learning and are unique to humans.
Objectives:
- To use magnetic resonance imaging to study areas of the brain involved in sound memory.
Eligibility:
- Healthy right-handed volunteers between 18 and 50 years of age. They must be native English
speakers and have completed high school.
Design:
- The study requires a screening visit and 1 or 2 study visits to the National Institutes
of Health Clinical Center.
- At the screening visit, volunteers will have a medical history taken. They will also
have physical and neurological exams, and complete a questionnaire. Women of
childbearing age will give a urine sample. Participants who have not had a magnetic
resonance imaging (MRI) scan in the past year will have one at this visit.
- At the second visit, participants will have tests of sound memory. They will listen to a
set of nonsense words spoken through earphones and memorize the words. Then they will
listen to the words again to judge if the words were part of the earlier list.
Participants will have a 1 hour break, then do the sound memory test again. During the
second test they will have repetitive transcranial magnetic stimulation (rTMS), which
stimulates different regions of the brain.
- If the group results from the testing sessions are positive, there will be a third
visit. At this visit, participants will have a sound perception test. They will listen
to words spoken through earphones and judge whether the words in the pair are the same
or different. Participants will have rTMS during these tests as well.
Status | Terminated |
Enrollment | 45 |
Est. completion date | October 30, 2015 |
Est. primary completion date | |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 40 Years |
Eligibility |
- INCLUSION CRITERIA: To be eligible for this research study participants must: Be between the ages of 18 and 50 years of age Be free of any neurologic condition that might affect performance of the tasks in these experiments Be right handed Be native English speakers Have a finished high-school education or equivalent, such as GED EXCLUSION CRITERIA: Participants will be excluded from this research study if they: Are taking medications that include antidepressants, anxiolytics, anticonvulsants, antipsychotics, antiparkinson, hypnotics, stimulants, and/or antihistamines Have a diagnosed neurologic or psychiatric condition Have a history of seizure disorder Have implanted devices such as pacemakers, medication pumps, or defibrillators, metal in the cranium except the mouth, intracardiac lines, history of shrapnel injury or any other condition/device that may contraindicate or preclude the acquisition of MRI Have severe back pain or any other condition which might prevent them from lying flat for up to 1 hour Have Claustrophobia (a fear of tight spaces), which prevents them from lying still in a tight or small space for up to 1 hour Are currently pregnant Have known hearing loss Have an alcohol or substance abuse problem as determined by the screening we will do |
Country | Name | City | State |
---|---|---|---|
United States | National Institutes of Health Clinical Center, 9000 Rockville Pike | Bethesda | Maryland |
Lead Sponsor | Collaborator |
---|---|
National Institute of Neurological Disorders and Stroke (NINDS) |
United States,
Aggleton JP, Brown MW. Interleaving brain systems for episodic and recognition memory. Trends Cogn Sci. 2006 Oct;10(10):455-63. Epub 2006 Aug 28. — View Citation
Alloway TP, Alloway RG. Investigating the predictive roles of working memory and IQ in academic attainment. J Exp Child Psychol. 2010 May;106(1):20-9. doi: 10.1016/j.jecp.2009.11.003. Epub 2009 Dec 16. — View Citation
Andoh J, Artiges E, Pallier C, Rivière D, Mangin JF, Cachia A, Plaze M, Paillère-Martinot ML, Martinot JL. Modulation of language areas with functional MR image-guided magnetic stimulation. Neuroimage. 2006 Jan 15;29(2):619-27. Epub 2005 Sep 15. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | The primary outcome of this study is the error rate during the recognition memory task. The error rate is defined by the amount of stimuli that are correctly classified as familiar or unfamiliar. | |||
Secondary | The secondary outcome measure of this study is the reaction time of participants to make judgments concerning the familiarity during the recognition memory task. |
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