Healthy Clinical Trial
Official title:
Importance of the GH/IGF-1 Axis for Human Substrate and Energy Metabolism During Calorie Restriction
This study will investigate whether growth hormone is modulated by the enzyme SIRT1 and by that is stimulating lipolysis on expense of IGF-I production. This is done in 10 healthy men on calorie restriction on 4 study days with fat and skeletal muscle biopsies.
It has been shown that calorie restriction enhances the length of life in yeast, worms, fish
and rodent. Whether this elongation of life due to calorie restriction can be applied to
humans is not known. However, it is a fact that calorie restriction will decrease the risk
of developing metabolic disturbances such as diabetes, hypertension and atherosclerosis.
On the molecular level the specific relations are not fully understood. This study will
investigate the possible connection between SITR1 and the relation to the GH/IGF-I axis and
STAT5b in healthy men. The participant will fast 42 and 12 hours respectively, and have GH
or placebo infusions. The design is a classical 2x2 design and will be randomized.
Knowledge of the interactions between calorie restriction, SIRT1, STAT5b and the GH/IGF-I
axis will apply important information about the relations between aging, energy metabolism
and metabolic disturbances.
;
Allocation: Randomized, Intervention Model: Factorial Assignment, Masking: Single Blind (Subject), Primary Purpose: Basic Science
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