Healthy Clinical Trial
Official title:
Vitamin D Deficiency in Adolescent Girls
Fibroblast growth factor 23 (FGF23) is a newly discovered hormone which regulates phosphate and vitamin D levels. In this study, we are looking at what the normal levels of FGF23 are in adolescent girls and how these levels vary with other hormonal measurements. We will also be looking at whether vitamin D supplementation in adolescents who are deficient in vitamin D alters the levels of FGF23 and other factors including insulin resistance.
Fibroblast growth factor 23 (FGF23) is a newly discovered hormone. Its primary function is
to regulate phosphate metabolism, which it does both by directly regulating phosphate
excretion through the kidney as well as by regulating vitamin D activity. What controls
FGF23 levels is still under investigation; potential factors include dietary phosphate
intake and vitamin D levels.
In this pilot study, we aim to investigate what the normal levels of FGF23 are in healthy
girls and how these are related to other measurements of bone and mineral metabolism. Since
vitamin D deficiency is very common in healthy girls, we expect a subset of the subjects in
this study to be vitamin D deficient. We will then randomize these girls to vitamin D
repletion or placebo and follow changes in FGF23 levels. Vitamin D deficiency has also been
implicated in insulin resistance which is a precursor to diabetes. We will therefore also
look at changes in insulin resistance with vitamin D repletion.
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Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Basic Science
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