Pilot Study on the Tolerability of Dietary Dried Plum

Healthy Clinical Trial

Official title:

Pilot Study on the Tolerability of Dietary Dried Plum

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01035372
• Other study ID #: H592-34987-01
• Status: Completed
• Phase: N/A
• Start date: December 2009
• Est. completion date: September 2010

Study information

• Verified date: February 2020
• Source: University of California, San Francisco
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Dried plums (Prunus domestica L.) have traditionally been recognized for their health benefits related to conditions such as constipation, irregular menstrual cycles and mouth sores. This dried fruit provides high levels of fiber, vitamins and minerals. Dried plum has also been shown in animal studies to have beneficial effects on bone and can prevent the loss of bone caused by low hormone levels such as occurs after surgical removal of the ovaries. We also have shown that dried plum can prevent the loss of bone associated with aging in mice. Very few therapies for osteoporosis actually reverse bone loss and improve bone strength. The potential therapeutic value of dried plum in men and women with hormone deficiency or age-related osteoporosis is clear.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 6
• Est. completion date: September 2010
• Est. primary completion date: September 2010
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 50 Years to 75 Years

Eligibility

Inclusion Criteria:

• Age between 50 yrs and 75 yrs

• Nonsmokers

• Normal renal and hepatic function

Exclusion Criteria:

• Subjects who must follow a specific diet

• Subjects on any daily medications that affect bone health

• Subjects too heavy for the DEXA machine (weight limit 300 lbs)

• Subjects whose BMD by DEXA indicates osteoporosis

• Subjects unwilling to follow the diet specified

• Pregnant women

• Subjects who are unable to understand the consent form.

Related Conditions & MeSH terms

• Elderly
• Healthy

Intervention

Dietary Supplement:
• dried plum powder
subjects will have 25% of their diet substituted by dried plum powder

Locations

Country	Name	City	State
United States	University of California San Francisco	San Francisco	California

Sponsors (1)

Lead Sponsor	Collaborator
University of California, San Francisco

Country where clinical trial is conducted

United States, 

References & Publications (1)

Deyhim F, Stoecker BJ, Brusewitz GH, Devareddy L, Arjmandi BH. Dried plum reverses bone loss in an osteopenic rat model of osteoporosis. Menopause. 2005 Nov-Dec;12(6):755-62. Epub 2005 Nov 8. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	urinary calcium excretion		one month
Secondary	ability to tolerate the diet		one month