Investigation of the Effects of Exercise on Gene Expression

Healthy Clinical Trial

Official title:

Investigation on Gene Expression and Gene Marker Accompanied by a Single Bout of Exercise and Exercise Training

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00916019
• Other study ID #: 19200049
• Status: Completed
• Phase: N/A
• First received: June 4, 2009
• Last updated: June 15, 2009
• Start date: July 2002
• Est. completion date: December 2007

Study information

• Verified date: June 2009
• Source: Fukuoka University
• Contact: n/a
• Is FDA regulated: No
• Health authority: Japan: Ministry of Education, Culture, Sports, Science and Technology
• Study type: Interventional

Clinical Trial Summary

The investigators have previously shown that mild exercise training at the level of lactate threshold (LT) intensity (60 min/day, 5 days/week) improves peripheral insulin sensitivity and insulin-independent glucose disposal of glucose effectiveness, without changes in body weight and body fat (Nishida et al, Diabetes Care, 2001; Nishida et al, Diabetes, 2004). Thus these beneficial effects are likely related to a number of adaptations that occur in skeletal muscle as response to exercise. In the current study, the investigators hypothesised that a single bout of mild exercise performed at LT would be a physiological stimulator of skeletal muscle PGC-1alpha gene, and the repetition of this exercise stimulating PGC-1alpha gene (i.e., training) for 12 weeks would induce coordinated increases in a large number of metabolic genes, as well as other genes potentially important in the prevention of insulin resistance and metabolic syndrome.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 6
• Est. completion date: December 2007
• Est. primary completion date: December 2007
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 19 Years to 32 Years

Eligibility

Inclusion Criteria:

• Men who were all in good health

• All individuals were free from diabetes and none were taking any medications

• All subjects were asked not to change their normal dietary habits, and not to engage in any strenuous physical activity

Exclusion Criteria:

• People who undergone regular exercise for at least 2 years

• Smokers

Study Design

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Healthy

Intervention

Other:
• exercise training
60 min of low-intensity exercise, 5 days/week, 12 weeks

Locations

Country	Name	City	State
Japan	Fukuoka University	Fukuoka

Sponsors (1)

Lead Sponsor	Collaborator
Fukuoka University

Country where clinical trial is conducted

Japan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Skeletal muscle PGC-1alpha gene expression and mitochondrial gene expression		3 months	No