Healthy Clinical Trial
Official title:
Role of Nitric Oxide in Optic Nerve Head Blood Flow Regulation During Experimental Increase of Intraocular Pressure in Healthy Humans
Autoregulation is defined as the ability of a vascular bed to adapt its vascular resistance
to changes in perfusion pressure. In the eye, several studies have reported that retinal
blood flow is autoregulated over a wide range of ocular perfusion pressures. Large scale
studies have shown that reduced ocular perfusion pressure is an important risk factor for
the prevalence, the incidence and the progression of primary open angle glaucoma.
Former studies that investigated ocular blood flow autoregulation focused mainly on
choroidal blood flow. For the optic nerve head only few data are available, although it
seems likely that it underlies similar autoregulatory mechanisms.
A previous study investigating choroidal blood flow has shown that nitric oxide (NO) plays a
key role in choroidal autoregulation. The present study is designed to test the hypothesis
that NO plays a role in optic nerve head autoregulation during increased intraocular
pressure (IOP). Therefore, IOP will be experimentally increased using a suction cup device
in the absence of presence of either a nitric oxide synthase inhibitor (L-NMMA), an
α-receptor agonist (phenylephrine) or placebo. Optic nerve head blood flow will be
continuously measured during the procedure.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Basic Science
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