Healthy Clinical Trial
Official title:
An Open-label Pharmacokinetic Drug Interaction Study of Folic Acid and 250 Mcg NGM/35 Mcg EE (ORTHO-CYCLEN) in Healthy Women..
The purpose of the study is to assess the effect of folic acid administration on the blood level and the breakdown products of OC study drug (250 mcg norgestimate[NGM]/35 mcg Ethinyl Estradiol [EE]) tablets. The effect of study drug tablet intake on the blood level of folic acid is also determined.
This is a single-center, open-label, pharmacokinetic drug interaction study between folic
acid (1 mg) and study drug (250 mcg NGM/35 mcg EE) in 2 groups of at least 20 healthy women
each. In Group 1, a single oral dose of 250 mcg NGM/35 mcg EE study drug was administered to
the healthy volunteers at the study site on Days 1 and 17 and folic acid 1 mg was
administered orally on Days 4 to 18; in Group 2, folic acid 1 mg was administered orally on
Days 1 and 17 at the study site and 1 tablet of study drug was administered on Days 2 to 17.
Blood samples were collected at specified times for 72 hours postdose on Days 1 and 17 for
the healthy volunteers in Group 1 for determination of blood levels of norelgestromin
(NGMN), and norgestrel (NG) [the active breakdown product of NGM], and EE. For the healthy
volunteers in Group 2, blood samples were collected for 24 hours after the folic acid dose
on Days 1 and 17 for determination of plasma levels of total folates. Safety was evaluated
based on the following: the incidence, type and severity of adverse events; clinical
laboratory tests; vital sign and electrocardiogram (ECGs) measurements; and physical
examinations. Oral temperature, pulse, respiratory rate, and sitting blood pressure (BP)
were taken before dosing on Days 1 and 17. For Group 1, measurements were taken before and
at least 15 minutes after the 24-hour (Days 2 and 18), 48-hour (Days 3 and 19), and 72-hour
(Day 4) pharmacokinetic blood draw; and at study completion (Day 20) or early withdrawal.
For Group 2, measurements were taken before and at least 15 minutes after the 24-hour
pharmacokinetic blood draw on Days 2 and 18; and at study completion (Day 18) or early
withdrawal. Physical and gynecologic examinations and 12-lead ECGs were performed at
screening and at study completion or early withdrawal. Blood samples for blood chemistry,
hematology, and urine samples for urinalysis were collected at the screening visit and at
the follow-up visit or early withdrawal.
Oral contraceptives tablet (250 mcg NGM/35 mcg EE); Folic acid tablet (1 mg). In Group 1, a
single oral dose of (250 mcg NGM/35 mcg EE) study drug was administered on Days 1 and 17 and
folic acid 1 mg was administered orally on Days 4 to 18; in Group 2, folic acid 1 mg was
administered orally on Days 1 and 17 and 1 tablet of study drug was administered on Days 2
to 17. Study drugs were taken with 240 mL (8 oz) of water at approximately 8:00 a.m.
;
Allocation: Randomized, Endpoint Classification: Pharmacokinetics Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
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