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PCR-Based Detection of Bacterial Agents in Platelet Concentrates and Whole Blood

Healthy Clinical Trial

Official title:
PCR-Based Detection of Bacterial Agents in Platelet Concentrates and Whole Blood (First Study)

Clinical Trial Summary

Using methods of molecular biology bacteria can be detected in blood. In comparison to conventional blood cultures "bacterial DNA" is isolated using a new sample preparation system in platelet apheresis concentrates and in the predonation whole blood of donors.

Clinical Trial Description

Bacterial contamination of platelet concentrates is discussed worldwide and according to literature occuring in 1:1000 to 1:5000 concentrates. Bacterial contaminated concentrates can in fact cause severe infections in patients. therefore this study initially intends to detect contamination with "bacterial DNA" in platelet aphereses concentrates. All sample donations are also examined by blood culture for contamination. To exclude already existing "infection" of the donor one tube of whole blood is taken in addition to the other legally required samples for the production of pharmaceutical medicine. All samples are anonymised before passed on for analysing. ;

Study Design

Allocation: Random Sample, Primary Purpose: Screening, Time Perspective: Cross-Sectional

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00482339
Study type Observational
Source University of Jena
Contact
Status Not yet recruiting
Phase N/A
Start date June 2007
Completion date July 2009
View Details
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