Healthy Clinical Trial
Official title:
Associations Between Gene-Polymorphisms, Endo-Phenotypes for Depression and Antidepressive Treatment (AGENDA)
The purpose of this study is to determine whether outcome following antidepressant treatment can be used as a tool to evaluate endo-phenotypes for depression.
The research in depression has for some years focused at the identification of
endo-phenotypes. Endo-phenotypes are heritable biological or psychological markers, which
are more commonly found in patients and their healthy relatives than in the general
population.
Recent studies point at disturbed regulation of the hypothalamic-pituitary-adrenocortical
(HPA) system as a possible endo-phenotype for depression.
The hypothesis of AGENDA are that endo-phenotypes are affected by treatment with
antidepressants in healthy first degree relatives.
AGENDA is a four week randomized, placebo-controlled, double-blind trial in which first
degree relatives of patients with the diagnosis of depression are randomised in to two
groups, which are treated with either placebo or antidepressant medicine (Cipralex). We
expect to include 80 healthy subjects, with the predisposition for depression, since one of
their parents or siblings recently was treated for depression.
The subjects will be examined before and after four weeks of treatment by a thorough
interview concerning psychiatric symptoms (SCAN), including depressive symptoms,
personality, perceived stress and cognitive function. The effect of antidepressant on stress
is measured with saliva-cortisol and by the response to the combined dexamethasone
corticotropin-releasing (CRH) hormone test. Additionally, MR and PET scans of the 5-HT4
receptor function will be conducted before and after 4 weeks of treatment.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Diagnostic
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