Healthy Clinical Trial
Official title:
Neurophysiological Studies of Focal and Generalized Forms of Dystonia Using Transcranial Magnetic Stimulation (TMS)
This study will use transcranial magnetic stimulation to examine how the brain controls
muscle movement in focal and generalized types of dystonia. Dystonia is a movement disorder
in which involuntary muscle contractions cause uncontrolled twisting or abnormal postures.
Dystonia may be focal, involving just one region of the body, such as the hand, neck or
face. Focal dystonia usually begins in adulthood. Generalized dystonia, on the other hand,
generally begins in childhood or adolescence. Symptoms begin in one area and then become
more widespread.
Healthy normal volunteers and patients with focal or generalized dystonia 8 years of age and
older may be eligible for this study. First-degree relatives of patients will also be
enrolled.
In transcranial magnetic stimulation, an insulated wire coil is placed on the subject's
scalp and brief electrical currents are passed through the coil, creating magnetic pulses
that pass into the brain. These pulses generate very small electrical currents in the
cortex-the outer part of the brain-briefly disrupting the function of the brain cells in the
stimulated area. The stimulation may cause muscle twitching or tingling in the scalp, face
and limbs. During the stimulation, the subject will be asked to either keep the hand relaxed
or to slightly tense certain muscles in the hand or arm. The test will last about 1.5 hours.
The cause of dystonia is unknown. It is hoped that a comparison of brain activity in normal
volunteers, patients and their relatives not affected by dystonia will help scientists learn
why some people develop dystonic movements.
Status | Completed |
Enrollment | 120 |
Est. completion date | July 2005 |
Est. primary completion date | |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | N/A and older |
Eligibility |
INCLUSION CRITERIA - Healthy Volunteers: Healthy Volunteers entered into the study must be free of serious somatic disease as determined by a standard physical and neurological examination. INCLUSION CRITERIA - Patients: For patients, the only selection criteria are the presence of primary dystonia, either focal or generalized (DYT1). Children aged 8 years or older will be included. Gender, ethnic origin and race will not be biased for inclusion. EXCLUSION CRITERIA: The exclusion criteria for this study include subjects who have a pacemaker, an implanted medication pump, a metal plate in the skull, metal objects inside the eye or skull (for example, after brain surgery or a shrapnel wound) or any recent (less than 3 months) brain lesions. |
N/A
Country | Name | City | State |
---|---|---|---|
United States | National Institute of Neurological Disorders and Stroke (NINDS) | Bethesda | Maryland |
Lead Sponsor | Collaborator |
---|---|
National Institute of Neurological Disorders and Stroke (NINDS) |
United States,
Fahn S. Concept and classification of dystonia. Adv Neurol. 1988;50:1-8. Review. — View Citation
Hallett M. The neurophysiology of dystonia. Arch Neurol. 1998 May;55(5):601-3. Review. — View Citation
Nutt JG, Muenter MD, Melton LJ 3rd, Aronson A, Kurland LT. Epidemiology of dystonia in Rochester, Minnesota. Adv Neurol. 1988;50:361-5. — View Citation
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