Healthy Clinical Trial
Official title:
Examination of the Hemodynamics of the Portal Venous System in Normal Volunteers Using Magnetic Resonance Imaging
This study will use magnetic resonance imaging (MRI) to examine blood flow patterns in the
arteries and veins of the liver and abdomen. It will 1) determine the best way to measure
blood flow in these vessels, and 2) make detailed measurements of the blood flow patterns of
these vessels. Information about normal liver blood flow may help explain the role of blood
flow in liver disease.
Normal healthy volunteers 18 years of age and older may be eligible for this study. They
will undergo MRI-a diagnostic tool that uses a strong magnetic field and radio waves to show
structural and chemical changes in tissue and the speed of moving blood. The patient lies on
a stretcher inside a metal cylinder (the scanner) for 1 to 1.5 hours and will be required to
lie very still for 10 to 15 minutes at a time. Blood pressure, heart rate, breathing and the
amount of oxygen in the fingertip are measured during the scan.
The involvement of the liver by certain disease processes is non-uniform and may be related to hepatic anatomy and the dynamics of portal blood flow. These differences may result from inhomogeneous delivery of hepatic toxins or trophic substances, tumor secretion products or tumor metastases to different portions of the liver. In addition to effects on the natural history of hepatic disease, these features may affect the performance (planning/methods) and interpretation of diagnostic studies, such as hepatic venous sampling for measurement of tumor secretion products. This study will combine non-invasive quantitative in vivo measurements of blood flow with in vitro modeling of the vascular system. The purpose of the study is to define the normal hemodynamics of hepatic blood flow, particularly portal flow, using Magnetic Resonance Angiography (MRA) and to draw inferences regarding the role of hemodynamics in the natural history of hepatic disease. ;
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