Healthy Volunteers Clinical Trial
Official title:
Lactobacillus Plantarum P8 for Its Brain Health Promotion Potential
This project aims to study the benefits of probiotics namely Lactobacillus plantarum P8 for brain health properties, primarily alleviation of stress, among adults in Malaysia aged from 18 to 60 years.
The emerging concept of gut-brain-axis has been implying that gut health plays a pivotal role
in maintaining brain health4. Probiotics have entered the picture in promoting gut health for
better brain health. Probiotic can be defined as "live microorganisms that grant health
effects to the host if consumed in sufficient amounts". Lactobacilli, as one of the largest
genera for probiotic microorganisms have been researched to alleviate stress, anxiety and/or
depression disorders.
L. plantarum P8 was isolated from traditionally fermented sour milk samples collected from
herdsmen in Wulatezhongqi grassland, Bayannaoer, Inner Mongolia, China. L. plantarum P8 was
selected as it was the best among 347 other Lactobacillus strains with excellent tolerance to
gastric acid, intestinal fluid and bile salt of the digestive system. P8 is incorporated and
sold in the market of China, Taiwan and Singapore in a variety of products, ranging from
dairy (yoghurt and fermented milk), health supplements to pet foods. P8 is patented in China
and also awarded by the Chinese government as a functional probiotic. Two human clinical
trials have shown that the administration of P8 at a concentration of 10 log CFU/day for
4-weeks, improved gastrointestinal health of adults subjects via increasing the population of
beneficial gut microbiota accompanied by decreasing gut opportunistic pathogens, increasing
fecal levels of secretory immunoglobulin-A and short chain fatty acids.
Thus, with evidence from other studies supporting the stress-alleviation effects of
lactobacilli and the current gut modulation properties of P8, we believe that L. plantarum P8
could exert stress alleviation potentials as well.
P8 has confirmed its safety for consumption, and for this intervention, it will be produced
under ISO9001 and HALAL in China. HALAL certification is provided by ARA HALAL Development
Services Center Inc. (ARA), which is recognized by JAKIM, Malaysia, an organization that
oversees the implementation of Halal requirement in Malaysia.
A total number of 176 healthy adults from age 18 -60 years old will be recruited for this
study.
;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT05029518 -
3-Way Crossover Study to Compare the PK (Pharmokinetics) and to Evaluate the Effect of Food on the Bioavailability
|
Phase 1 | |
Completed |
NCT05001152 -
Taste Assessment of Ozanimod
|
Phase 1 | |
Completed |
NCT04493255 -
A Study to Determine the Metabolism and Elimination of [14C]E7090 in Healthy Male Participants
|
Phase 1 | |
Completed |
NCT03457649 -
IV Dose Study to Assess the Safety, Tolerability, PK, PD and Immunogenicity of ARGX-113 in Healthy Volunteers
|
Phase 1 | |
Completed |
NCT00995891 -
Collection of Blood, Bone Marrow, and Buccal Mucosa Samples From Healthy Volunteers for Center for Human Immunology, Autoimmunity, and Inflammatory Diseases (CHI) Laboratory Research Studies
|
||
Completed |
NCT05050318 -
Annual Study for Collection of Serum Samples in Children and Older Adults Receiving the 2021-2022 Formulations of Fluzone Quadrivalent Vaccine and Fluzone High-Dose Quadrivalent Vaccine, Respectively
|
Phase 4 | |
Completed |
NCT05043766 -
Evaluation of Oral PF614 Relative to OxyContin
|
Phase 1 | |
Completed |
NCT04466748 -
A Multiple Ascending Dose Pharmacology Study of Anaprazole in Healthy Chinese Subjects
|
Phase 1 | |
Completed |
NCT00746733 -
Vyvanse and Adderall XR Given Alone and in Combination With Prilosec OTC
|
Phase 1 | |
Recruiting |
NCT05929651 -
Study of Immunogenicity and Safety of MenQuadfi® as a Booster Vaccine in Toddlers 12 to 23 Months, Regardless of the Quadrivalent Meningococcal Conjugate Vaccine Used for Priming in Infancy
|
Phase 4 | |
Completed |
NCT05954039 -
Evaluation of the Efficacy of a Dietary Supplement on Hair Loss and Hair Aspect
|
N/A | |
Completed |
NCT05045716 -
A Study of Subcutaneous Lecanemab in Healthy Participants
|
Phase 1 | |
Active, not recruiting |
NCT02747927 -
Efficacy, Safety and Immunogenicity of Takeda's Tetravalent Dengue Vaccine (TDV) in Healthy Children
|
Phase 3 | |
Completed |
NCT05533801 -
A Study to Demonstrate the Bioequivalence of Lecanemab Supplied in Vials and a Single-Use Auto-Injector (AI) in Healthy Participants
|
Phase 1 | |
Not yet recruiting |
NCT03931369 -
Adaptation of Thirst to a Single Administration of Tolvaptan (TOLVATHIRST)
|
Phase 2 | |
Completed |
NCT03279146 -
A Single Dose Study Evaluating PK of TXL Oral Formulations in Healthy Subjects
|
Phase 1 | |
Completed |
NCT06027437 -
A Study to Assess the Relative Biological Availability and the Effect of Food on the Drug Levels of Danicamtiv in Healthy Adult Participants
|
Phase 1 | |
Recruiting |
NCT05619874 -
Effects of Two Virtual HIFCT Programs in Adults With Abdominal Obesity
|
N/A | |
Completed |
NCT05553418 -
Investigational On-body Injector Clinical Study
|
N/A | |
Completed |
NCT04092712 -
Study Evaluating Pharmacokinetics and Mass Balance of [14C]-CTP-543 in Healthy Adult Male Volunteers
|
Phase 1 |