View clinical trials related to Healthy Volunteers.
Filter by:This study will assess up to 12 different oral formulations of apremilast to determine how much apremilast is absorbed by the body compared to a reference formulation.
To evaluate the metabolism and excretion of [14C]-CC-122 in healthy male subjects
Background: - Brain stimulation called repetitive transcranial magnetic stimulation (rTMS) may help people quit drugs. Researchers want to study how it works in healthy people first. Objective: - To learn how to use rTMS to stimulate a brain area and to see how it affects brain function and thinking. Eligibility: - Healthy, right-handed adults ages 18-55. Design: - Participants will be screened under another protocol. - They will have 4-11 study visits. - To start each visit, participants will have: - Physical exam. - Urine sample. - Breath tests for alcohol and cigarette smoke. - Questions about drug use and medications. - Visit 1: participants will have: - Single TMS pulses on the head to determine the right strength. They will wear earplugs and a cap. A wire coil will be placed on the head and an electrical current will go through it. Participants may perform simple muscle movements. They will repeat the procedures wearing another coil, in a helmet. - A few TMS pulses to show how rTMS feels. - A practice thinking task, maybe in a scanner that looks and sounds like a magnetic resonance imaging (MRI) scanner but does not take pictures. The MRI scanner is a metal cylinder surrounded by a strong magnetic field. The participant will lie on a table that slides in and out of the cylinder. - They may have a real MRI scan. - Visits 2-11, participants will: - Complete two questionnaires. - Get varied rTMS stimulation. Their heart rate and blood pressure may be monitored. - Have their vital signs checked. - They may perform thinking tasks at a computer, in a mock scanner, or in an MRI scanner. They may just lie still in the MRI scanner.
The purpose of this study is to: determine the effect of stomach pH on the multiple dose pharmacokinetics (PK) of gefapixant (AF-219); assess the effect of multiple doses of gefapixant on various sensory assessments; and, assess the safety and tolerability of gefapixant.
This is a single center, randomized, controlled, within-subject comparison, multiple dose study to determine the irritation potential of M518101 on normal skin under occlusive patch condition. The study drug will be applied for 21 days under occlusive patch condition. The irritation potential of M518101 will be compared with positive, negative control and M518101 vehicle. The study duration is 21days and there will be at least 23 visits to study center including screening visit.
Study to evaluate the effect of intake of food in comparison to fasting condition on pharmacodynamics of AZD1722 following a twice-daily administration of AZD1722 tablet formulation
The purpose of this study is to determine if two different dosing strategies for evacetrapib will have essentially the same effect on the body. The study will also explore the effect of a low fat meal on how the body absorbs evacetrapib. This study will last at least 15 weeks, not including screening. Screening is required within 28 days prior to the date of first dosing.
This is a Phase 1, open-label, 2-period fixed sequence design to evaluate the interaction of AZD9291 with omeprazole in approximately 50 healthy, adult male volunteers. Volunteers will receive Treatment A (AZD9291 and omeprazole) in Period 1 and Treatment B (AZD9291 only) in Period 2. The dose of AZD9291 in Period 1 and the dose of AZD9291 in Period 2 will be separated by a washout of at least 21 days (the washout will not be more than 5 weeks). The study will be performed at up to 2 sites in the USA and will assess the effect of omeprazole (proton pump inhibitor) on AZD9291 exposure
AG-221 is a first-in-class drug targeted specifically to inhibit the IDH2 enzyme. Small molecule inhibition of the IDH enzyme represents a new, targeted approach to cancer treatment. Administration of oral drugs with food may change the absorption of drugs, and it is therefore useful to characterize the effect of food early in drug development.
Slacklines have been established in the last few years as a training equipment in sports such as climbing, skiing and others to increase postural control. Furthermore, slacklines are used in physiotherapy in terms of stabilizing training such as wobbling boards. However, if slackline training is effective in rehabilitation has not been investigated yet. Therefore, to goal of this study will be to investigate the effectivity of slackline training in physiotherapy compared to a wobbling board with a single tilting axis. Outcomes will be electromyographic-data and the kinetics of the whole body.