Biomarkers of iNOS Activity in COPD, Asthma, Healthy Control

Healthy Smokers Clinical Trial

Official title: A Pilot Study to Evaluate and Develop Biomarkers of iNOS Activity in Patients With COPD or Asthma and Healthy Volunteers

Status Withdrawn

Clinical Trial Summary

This pilot study will measure the baseline levels and the intra- and inter-subject variability of exhaled (alveolar and bronchial) and nasal NO in smoking subjects with mild and moderate COPD on or off steroid treatment, smoking healthy volunteers and non-smoking mild asthmatics off steroids, using multiple exhalation flow rates.

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Clinical Trial Description

n addition, exploratory markers of iNOS activity (eg. 3-nitrotyrosine, nitrite, nitrate and 3-nitro-4-hydoxyphenylacetic acid) in blood, sputum, urine and exhaled breath condensate will be evaluated. We will also evaluate exhaled and nasal NO in a population of mild asthmatics in order to obtain baseline and variability data for future clinical studies involving asthmatic subjects. ;

Related Conditions & MeSH terms

• Asthma
• Healthy Non-smokers
• Healthy Smokers
• Patients With Mild Asthma
• Patints With COPD (GOLD II)

• NCT number: NCT00159302
• Study type: Observational
• Source: Imperial College London
• Status: Withdrawn
• Start date: September 2003
• Completion date: September 2006