Resistance Training and Hydrolyzed Collagen Supplementation in Healthy Young Adults

Healthy Participants Clinical Trial

Official title:

The Effects of Resistance Training With Hydrolyzed Collagen Supplementation on Muscle and Tendon Adaptation in Healthy Young Adults

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT06372080
• Other study ID #: 19/SPS/054
• Status: Completed
• Phase: N/A
• Start date: January 6, 2020
• Est. completion date: March 31, 2023

Study information

• Verified date: February 2024
• Source: Liverpool John Moores University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The goal of this clinical trial is to investigate the effects of resistance training with hydrolyzed collagen ingestion on changes in muscle and tendon adaptation in healthy young men and women.

The main questions it aims to answer are:

• Does resistance training with hydrolyzed collagen ingestion lead to greater changes in tendon properties than resistance training alone?

• Does resistance training with hydrolyzed collagen ingestion lead to greater changes in muscle size than resistance training alone?

Participants will be randomly assigned to collagen or placebo groups. Participants will perform resistance training three times per week for 10 weeks and hydrolyzed collagen or maltodextrin will be given to collagen or placebo group respectively immediately before each resistance training session. Also, vitamin C will be given to both groups.

Researchers will compare collagen and placebo groups to see if hydrolyzed collagen ingestion with resistance exercise would have beneficial effects on changes in muscle and tendon more than resistance training alone. Therefore, using isokinetic dynamometer and ultrasonography, maximal leg strength, morphological, mechanical, and material properties of the patellar tendon and vastus lateralis muscle size and architecture will be assessed.

Description:

Young, healthy, active men and women will ingest 30 grams of hydrolyzed collagen or a calorie matched beverage (maltodextrin) alongside vitamin C prior to performing high-intensity resistance training 2 - 3 times per week for 10 weeks.

The aim of this study is to investigate the effect of combining hydrolyzed collagen supplementation with resistance training in young men and women. If supplementation with hydrolyzed collagen leads to a greater change in tendon size, stiffness, and Young's modulus than resistance training alone, this will allow us to recommend this type of intervention to young athletes seeking to improve tendon health and/or athletic performance.

The experimental design and measurements will be the same in the Arm 1 and Arm 2 but the differences will be sex where participants in Arm 1 will be healthy young men while participants in Arm 2 will be healthy young women.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 23
• Est. completion date: March 31, 2023
• Est. primary completion date: September 29, 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 39 Years

Eligibility

Inclusion Criteria:

• Healthy young male or female

• No history of patellar tendon injuries in the past 6 months

• No history of lower limb musculoskeletal injuries in the past 6 months

• Non-smokers (including e-cigarettes)

• Free from cardiovascular and metabolic diseases

• Nullipara (a woman who has never given birth)

Exclusion Criteria:

• Age less than 18 years or higher than 40 years

• Being vegan or vegetarian (due to the mammalian source of collagen)

• Consumption of nutritional supplementation that purportedly affects muscle-tendon adaptation or recovery (i.e. protein powder, vitamin C, collagen)

• BMI over 30 kg/m2

• Previous anterior cruciate ligament injury where the patellar tendon was used as a graft

Related Conditions & MeSH terms

• Exercise Training
• Healthy Participants
• Nutrition

Intervention

Dietary Supplement:
• Resistance training with hydrolyzed collagen ingestion in healthy young men
Participants in this intervention will be healthy young men. The information of nutritional supplements is below. Hydrolyzed collagen: 30 grams unflavored hydrolysed collagen (HC) (Myprotein, Cheshire, UK) 30.5 grams unflavored maltodextrin (Myprotein, Cheshire, UK) 50 milligrams vitamin C powder (Holland and Barrett Retail Limited, Warwickshire, UK) 3 grams non-caloric sweetener (Truvia®, SilverSpoon, London, UK)
• Resistance training with hydrolyzed collagen ingestion in healthy young women
Participants in this intervention will be healthy young women. The same nutritional supplements in Arm 1 wil be used in Arm 2.

Locations

Country	Name	City	State
United Kingdom	Research Institute for Sport and Exercise Sciences	Liverpool	Merseyside

Sponsors (1)

Lead Sponsor	Collaborator
Liverpool John Moores University

Country where clinical trial is conducted

United Kingdom, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Maximal knee extensor (quadriceps) muscle strength	Using isokinetic dynamometer, knee extensor maximal isometric voluntary contraction torque (in Newton meters) will be measured.	12 weeks (10 weeks' intervention plus one week either side for assessments)
Primary	Maximal knee flexor (hamstring) muscle strength	Using an isokinetic dynamometer, knee flexor maximal isometric voluntary contraction torque (in Newton meters) will be measured.	12 weeks (10 weeks' intervention plus one week either side for pre- and post-intervention assessments)
Primary	Patellar tendon cross-sectional area	Using ultrasonography, patellar tendon cross-sectional area (in millimeters squared) will be measured.	12 weeks (10 weeks' intervention plus one week either side for pre- and post-intervention assessments)
Primary	Patellar tendon stiffness	Using ultrasonography, patellar tendon stiffness (in Newtons per millimeter) will be measured.	12 weeks (10 weeks' intervention plus one week either side for pre- and post-intervention assessments)
Primary	Vastus lateralis (VL) muscle size	Using ultrasonography, the VL anatomical cross-sectional area (in centimeters squared) will be measured.	12 weeks (10 weeks' intervention plus one week either side for pre- and post-intervention assessments)
Primary	Vastus lateralis (VL) muscle fascicle length	Using ultrasonography, VL muscle fascicle length (in millimeters) will be measured.	12 weeks (10 weeks' intervention plus one week either side for pre- and post-intervention assessments)
Primary	Vastus lateralis (VL) muscle fascicle pennation angle	Using ultrasonography, VL muscle fascicle pennation angle (in degrees) will be measured.	12 weeks (10 weeks' intervention plus one week either side for pre- and post-intervention assessments)