Influence of tDCS on Cortical Plasticity in Healthy Older Adults

Healthy Older Adults Clinical Trial

Official title:

Influence of Transcranial Direct-current Stimulation on Cortical Plasticity in Healthy Older Adults

Clinical Trial Details — Status: Withdrawn

Administrative data

• NCT number: NCT01888055
• Other study ID #: Plasticity in healthy adults
• Status: Withdrawn
• Phase: N/A
• Start date: May 2013
• Est. completion date: December 2017

Study information

• Verified date: May 2021
• Source: Charite University, Berlin, Germany
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The aim of this study is to investigate whether the anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) in healthy older adults leads to an increase in cortical plasticity (change in motor evoked potentials (MEP) in mV).

Recruitment information / eligibility

• Status: Withdrawn
• Enrollment: 0
• Est. completion date: December 2017
• Est. primary completion date: October 2017
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 50 Years to 80 Years

Eligibility

Inclusion Criteria:

• right-handed according to the Oldfield Händigkeits inventory (lateralization index >70)(1971)
• no obvious cognitive impairment (MMSE>26, Demtect>13)
• age between 50 and 80 years

Exclusion Criteria:

• Severe neurological / psychiatric or pre-existing internist conditions because additional cognitive deficits are expected
• Epilepsy, epileptic seizure in medical history
• Cognitive deficit (MMSE <20)
• Depressive episode (Beck Depression Inventory (BDI) > 12)
• intake of centrally active drugs <3 months , particularly acetylcholinesterase inhibitors
• Pregnancy
• Pacemaker (contraindication for MRI)
• Other metal parts in the body (contraindication for MRI)

Related Conditions & MeSH terms

• Healthy Older Adults

Intervention

Device:
• transcranial direct current stimulation

• sham stimulation

Locations

Country	Name	City	State
Germany	Klinik und Poliklinik für Neurologie, Charité Universitätsmedizin Berlin	Berlin

Sponsors (1)

Lead Sponsor	Collaborator
Charite University, Berlin, Germany

Country where clinical trial is conducted

Germany, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) in healthy older adults	to investigate whether the anodal transcranial direct current stimulation over the primary motor cortex (M1) in healthy older adults increases cortical plasticity (measured via motor evoked potentials)compared to sham stimulation	1 week
Secondary	Comparison of tDCS-induced changes on central cholinergic activity	to investigate weather anodal transcranial direct-current stimulation affect central cholinergic activity (measured via a TMS-protocol) in healthy older adults compared to sham stimulation	1 week
Secondary	Comparison of tDCS-induced changes in the learning success	tDCS-induced changes on learning success (performance in a motor learning paradigm in healthy older adults after tDCS vs. sham)	1 week
Secondary	MR elastography	Comparison of viscoelastic parameters in cerebral MR elastography in healthy older adults	1 week
Secondary	genetic polymorphism, ApoE4	optional assessment of genetic Apo4 epsilon status for assessment of differences in cortical plasticity and elasticity between Apo4 epsilon positive and negative participants	once