Healthy, no Evidence of Disease Clinical Trial
Official title:
A Population Based Control Collection for Genetic Studies in East Anglia
RATIONALE: Studying samples of blood from healthy volunteers in the laboratory may help
doctors learn more about changes that occur in DNA and identify biomarkers related to
cancer.
PURPOSE: This study is looking at genetic susceptibility to cancer and interactions between
genes and the environment in healthy volunteers.
OBJECTIVES:
- To obtain blood samples and simple epidemiological information on a population-based
series of adult individuals without cancer.
- To establish whether polymorphisms in putative cancer predisposition genes are
associated with an increased risk of cancer by comparing the frequency of alterations
in these genes with the corresponding frequency in a comparable series of cancer
patients.
- To examine the interactions between genetic and non-genetic risk factors.
OUTLINE: This is a multicenter study.
Participants complete a simple epidemiological questionnaire.
Participants undergo blood sample collection. DNA is extracted from these samples for
polymorphism analysis of low penetrance cancer susceptibility genes in the following related
clinical trials: MREC-SEARCH-CANCER, MREC-SEARCH-PROSTATE, and MREC-SEARCH-BREAST. They may
also be used in the analyses of the following related clinical trials: MREC-SEARCH-OVARIAN,
MREC-SEARCH-ENDOMETRIAL, MREC-SEARCH-COLORECTAL.
PROJECTED ACCRUAL: A total of 2,000 male and 2,000 female participants will be accrued for
this study.
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N/A
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