Healthy Male Volunteers Clinical Trial
Official title:
An Open-Label Study To Evaluate D1 Receptor Occupancy (RO) Following a Single Dose of PF-06412562, Using Positron Emission Tomography (PET) With Ligand [18F]MNI-968 in Healthy Male Subjects
To assess the D1 receptor occupancy (D1 RO) in striatum after a single oral administration of PF-06412562.
Primary Objectives:
- To assess the D1 receptor occupancy (D1 RO) in striatum after a single oral
administration of PF-06412562
- To assess the relationship of D1 RO in the striatum versus plasma exposure of
PF-06412562 after a single oral administration.
Secondary Objective:
• To evaluate the plasma exposure of PF-06412562for the duration of PET scan following a
single oral administration of PF-06412562.
Safety Objectives:
• To evaluate the safety and tolerability of PF-06412562 of single oral doses of PF-06412562.
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