Healthcare Associated Pneumonia Clinical Trial
Official title:
Clinical Characteristics and Microbiology of Healthcare Associated Pneumonia
Background The prediction of multi-drug resistant (MDR) pathogens is a key issue in the
management of health-care associated pneumonia (HCAP). Multiple risk factors have been
proposed, some of which overlap with items of the pneumonia severity index (PSI). The aim of
this study was to investigate the relationship between PSI and presence of MDR pathogens.
Methods Patients who were admitted to a tertiary-care hospital from January 2005 to December
2010 were screened by a discharge diagnosis of pneumonia. Patients were enrolled if they
fulfilled the definition of HCAP by 2005 ATS/IDSA guideline.
MDR bacteria were defined as Pseudomonas aeruginosa (P. aeruginosa), Enterobacter species,
those not sensitive to second and third generation cephalosporins, Acinetobacter species,
extended-spectrum β-lactamase (ESBL) Enterobacteriaceae such as Escherichia coli (E. coli)
and Klebsiella pneumoniae (K. pneumoniae), Burkholderia cepacia (B. cepacia),
Stenotrophomonas maltophilia (S. maltophilia), and methicillin resistant Staphylococcus
aureus (MRSA).
The criteria for HCAP is defined as follows: patients who had been hospitalized in an acute
care hospital for two or more days within the past 90 days; residents of a nursing home or
long-term care facility; recipients of recent intravenous antibiotic therapy, chemotherapy or
wound care within the past 30 days; or patients who attended a hospital or hemodialysis
clinic.
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