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Headache clinical trials

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NCT ID: NCT05410366 Withdrawn - Low Back Pain Clinical Trials

Safe Harbors in Emergency Medicine, Specific Aim 3

Start date: September 30, 2022
Phase:
Study type: Observational

Many patients who present to the emergency department (ED) receive a vast array of diagnostic tests, some of which might not be useful. Providers often feel obligated to order so many tests to protect themselves against the risk of being sued. The investigators believe if a standard of care providing legal protection for certain clinical conditions were agreed upon and followed, unnecessary testing would significantly decrease in the ED, which, in turn, would improve patient safety, augment the quality of care delivered, and increase patient satisfaction.

NCT ID: NCT05337930 Withdrawn - Clinical trials for Primary Headache Disorder

Feasibility of a Developmentally-tailored Mobile App for Tracking Mood and Pain in Children With Migraine

Start date: August 4, 2022
Phase: N/A
Study type: Interventional

This study aims to inform the continued development of a mobile app intended to support the treatment of CYP with migraine. After extensive public and patient involvement, Happyr Health has developed a mobile app that allows children and young people to track headache attacks and emotional wellbeing and to access coping techniques. With the use of gamification and storytelling elements, the app aims to engage children to be an active part in tracking and coping with their headaches. The outcomes of this study will inform future adaptations and development cycles of the Happyr Health app. 15 participants aged 10-16 will access the Happyr app for 8 weeks (= intervention). Primary outcomes of acceptability and implementation will be measured via surveys following the 8-week intervention in the app.

NCT ID: NCT04580238 Withdrawn - Hemorrhagic Stroke Clinical Trials

Onabotulinum Toxin A (Botox) for the Treatment of Persistent Post-Stroke and Vascular Headache

Start date: December 2023
Phase: Phase 1
Study type: Interventional

Post stroke headache occurs in approximately 10-23% of all stroke patients. Its onset is shortly after experiencing a stroke, or stroke like event, and persists for at least three months. These headaches have features which resemble migraine or occur in people who have a previous history of migraine that was once infrequent. Botox is a treatment that is currently approved for the treatment of chronic migraine, that is migraine headaches occurring for at least 15 days a month for at least 3 months. Given the clinical similarity in character and frequency of post stroke headache and migraine, and the fact that stroke affects structures like the blood vessels in the brain that are also affected in migraine, this study is to investigate the possible role that Botox would have in the treatment of Post-Stroke Headache.

NCT ID: NCT04515901 Withdrawn - Clinical trials for Postdural Puncture Headache

Spenopalatine Ganglion Block for Treatment of Post-dural Puncture Headaches

SPGB
Start date: December 1, 2021
Phase: N/A
Study type: Interventional

Postdural puncture headache (PDPH) is a severe, debilitating complication of dural puncture that can arise from insertion of an epidural or spinal needle for labour analgesia. Presently, the conservative treatment options for PDPH have limited effectiveness and the gold standard treatment for PDPH, an epidural blood patch, is an invasive intervention with the potential for serious complications. There is a growing number of case reports and retrospective studies that suggest a sphenopalatine ganglion block (SPGB) with local anesthetic may offer an effective, safe, and easy-to-administer treatment option for PDPH in postpartum patients. We aim to conduct a feasibility study to assess whether a randomized controlled trial is feasible comparing whether early intervention SPGB with the option for repeat, patient self-administered SPGBs versus current standard conservative management can reduce the severity and duration of PDPH pain and improve patient functional status.

NCT ID: NCT04353505 Withdrawn - Chronic Migraine Clinical Trials

Intra-arterial Sphenopalatine Ganglion Block for Patients With Refractory Headache

Start date: October 2020
Phase: Phase 1
Study type: Interventional

The purpose of this study is to evaluate the safety and efficacy of intra-arterial (IA) delivery of Dexamethasone and Ketorolac into the arteries supplying the sphenopalatine ganglion (SPG) - a collection of neurons that plays an important role in headache disorders - in patients with refractory migraine, cluster headache and trigeminal neuralgia. All patients must fail standard treatments prior to enrollment in the trial.

NCT ID: NCT04071743 Withdrawn - Clinical trials for Post-Traumatic Headache

Study of Gammacore Sapphire for the Acute and Preventive Treatment of Post-Traumatic Headache (GAP-PTH)

Start date: January 1, 2020
Phase: N/A
Study type: Interventional

The purpose of this single-center, prospective, randomized, double-blind, sham controlled, parallel-group study is to collect clinical data related to the safety and efficacy of vagus nerve stimulation for the acute and preventive treatment of Post Traumatic Headache.

NCT ID: NCT03966547 Withdrawn - Clinical trials for Postdural Puncture Headache

Changes in Cerebral Blood Flow (CBF) in Prone and Sitting Position Before and After GSP-block and Before and After Epidural Blood-patch: A Substudy of NCT03652714

Start date: May 2020
Phase: N/A
Study type: Interventional

The purpose of this optional sub-study to GSPB-2018 (NCT03652714) is to evaluate the changes in cerebral blood flow (CBF) under different conditions to understand if postdural puncture headache is caused by changes in the cerebral blood flow and if treatment normalises that change.

NCT ID: NCT03908944 Withdrawn - Postoperative Pain Clinical Trials

Postoperative Pain and Headache After Craniotomy

Start date: January 2, 2019
Phase: Phase 2
Study type: Interventional

The purpose of this study is to assess the outcomes of an anesthetic technique which is not synthetic opioid based, on postoperative pain modulation and development of post craniotomy headache against a cohort of patients where an opioid based standard anesthetic technique was used for craniotomy. The hypothesis that is tested is that the use of agents other than synthetic short acting opioids will reduce the amount of postoperative pain and the incidence of headache after surgery.

NCT ID: NCT03560349 Withdrawn - Clinical trials for Post-Dural Puncture Headache

RCT of SPG Blocks for Post-dural Headache

Start date: July 1, 2018
Phase: Phase 2
Study type: Interventional

The purpose of the study is to assess the effectiveness of the SPG block with lidocaine vs. SPG block with placebo on preventing the need for EBP in women who develop PDPH after accidental dural puncture during placement of LEA for labor.

NCT ID: NCT03472872 Withdrawn - Headache Clinical Trials

A Comparative Efficacy Trial of IV Acetaminophen Versus IV Ketorolac for Emergency Department Treatment of Generalized Headache

Start date: September 5, 2017
Phase: Phase 4
Study type: Interventional

This randomized, double-blind trial will compare the clinical efficacy of IV acetaminophen to that of IV ketorolac as adjuncts to standard therapy (prochlorperazine and diphenhydramine) in the treatment of patients presenting to the emergency department with chief complaint of "headache" or variants thereof.