Head Injury Clinical Trial
— HIPPOfficial title:
The Head Injury-associated Photosensitivity and Pupillary Function (HIPP) Study
Verified date | September 2017 |
Source | Ohio State University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
After a head injury, many people find that exposure to light causes them increased discomfort. By measuring how the pupil in the eye constricts to flashes of red and blue light, this study will investigate whether this phenomenon is due to a change in the eye's sensitivity to light.
Status | Completed |
Enrollment | 40 |
Est. completion date | December 2015 |
Est. primary completion date | December 2014 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years and older |
Eligibility |
Inclusion Criteria: - 18+ years old - reports a previous head injury that occurred at least 6 months ago - score of 2 or 3 (mild TBI) on OSU-TBI ID Survey - best-corrected visual acuity of at least 20/30 in both eyes - reliable visual field Exclusion Criteria: - pregnancy - significant afferent pupillary defect - previous history of neurodegenerative disease - intraocular pressure more than 21 mm Hg - significant visual field defect - active corneal pathology - history of retinal or optic nerve disease - strabismus (eye turn) |
Country | Name | City | State |
---|---|---|---|
United States | College of Optometry | Columbus | Ohio |
Lead Sponsor | Collaborator |
---|---|
Ohio State University | U.S. Army Medical Research and Materiel Command |
United States,
Barker F, Cockerham G, Goodrich G, Hartwick A, Kardon R, Mick AB, Swanson M. Brain Injury Impact on the Eye and Vision. Optom Vis Sci. 2017 Jan;94(1):4-6. doi: 10.1097/OPX.0000000000001001. — View Citation
Yuhas PT, Shorter PD, McDaniel CE, Earley MJ, Hartwick AT. Blue and Red Light-Evoked Pupil Responses in Photophobic Subjects with TBI. Optom Vis Sci. 2017 Jan;94(1):108-117. doi: 10.1097/OPX.0000000000000934. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Pupil Responses | The pupil fluctuation evoked by blue and red flickering lights will be measured in patients with a prior brain injury and compared to matched controls. | 2 weeks | |
Secondary | Sleep Rhythms | Daily rhythms of sleep and activity will be assessed in subjects with prior brain injury and compared to matched controls. | 2 weeks | |
Secondary | Light Exposure | The exposure to red, blue and green components of the light spectrum will be quantified in patients with a prior brain injury, and compared to matched controls. | 2 weeks | |
Secondary | Photosensitivity Symptoms | Subjects will complete survey indicating symptoms they have experienced related to light sensitivity and will grade their discomfort after exposed to brief flashes of light. | Single visit - one day |
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