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Postoperative Management for HNSCC Based on Pathological Response of Induction Chemotherapy and Immunotherapy — HN  

Head and Neck Cancer Clinical Trial

Official title:
Pathological Response Adapted Decision-making of Postoperative Management for HNSCC Receiving Induction Immunotherapy and Chemotherapy

Clinical Trial Summary

To develop postoperative stratification treatment for patients who have received induction chemotherapy and immunotherapy in locally advanced head and neck cancers. Risk stratification is based on clinical characteristics and pathological responses. In order to achieve no inferior survival rate and a lower treatment-related toxicity rate than the standard treatment.

Clinical Trial Description

Induction chemotherapy combined with immunotherapy has shown promising efficacy in the treatment of patients with locally advanced head and neck cancers. However, how to choose a proper postoperative treatment remains unknown. Eligibility patients were assigned to two arms, each divided into three groups: observation, immunotherapy maintenance, and radiotherapy (50 Gy dose) plus immunotherapy maintenance group for low-risk arm; radiotherapy (50 Gy or 60Gy dose) plus immunotherapy maintenance groups, concurrent chemotherapy plus immunotherapy maintenance group for a high-risk arm. Disease-free survival, overall survival, and treatment-related toxicity would be calculated to evaluate the efficacy of treatments. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05777824
Study type Interventional
Source Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Contact Yi Xu
Phone 15811166516
Email 694818945@qq.com
Status Recruiting
Phase Phase 2
Start date January 1, 2023
Completion date December 30, 2027
View Details
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