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"QUAD SHOT" Radiotherapy With Pembrolizumab in Patients With Recurrent Head & Neck Cancer — QUADSHOT  

Head and Neck Cancer Clinical Trial

Official title:
A Single-arm Phase II Trial of Palliative "QUAD SHOT" Radiotherapy Combined With Pembrolizumab in Patients With Recurrent Head & Neck Cancer

Clinical Trial Summary

The purpose of this study is to test the safety of palliative "QUAD SHOT" radiotherapy combined with pembrolizumab and evaluate the effects of the combination treatment patients with recurrent cancer of head and neck.

Clinical Trial Description

During this study, patients will receive infusions of pembrolizumab with radiotherapy (palliative QUADSHOT regimen). The patient will receive treatment of pembrolizumab once every 3 weeks and palliative "QUAD SHOT" radiotherapy every 4 weeks. These 28 day period of time is called a cycle. The cycle will be repeated 3 times. Each cycle is numbered in order. The patient will be treated for up to 3 cycles followed by pembrolizumab single drug until unacceptable toxicity or tumor progression. The patient will also complete a survey. Total duration of the study is up to two years. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04373642
Study type Interventional
Source University of Oklahoma
Contact SCC IIT Office
Phone 405-271-8777
Email SCC-IIT-Office@ouhsc.edu
Status Recruiting
Phase Phase 2
Start date December 23, 2020
Completion date October 2025
View Details
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