Study Evaluating the Efficacy of Niraparib & Dostarlimab (TSR-042) in

Clinical Trial Description

Recurrent and/or metastatic HNSCC patients will be treated with combination of the PD-1 inhibitor (dostarlimab) and PARPi (niraparib) concurrently and ORR, PFS and OS will be determined. ;

Study Design

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05808920` - The RESCUE Study: Survival and Functional Outcomes Following Salvage Surgery for RESidual or reCurrent sqUamous cEll Carcinoma of the Head and Neck
Completed	`NCT02526017` - Study of Cabiralizumab in Combination With Nivolumab in Patients With Selected Advanced Cancers	Phase 1
Active, not recruiting	`NCT05060432` - Study of EOS-448 With Standard of Care and/or Investigational Therapies in Participants With Advanced Solid Tumors	Phase 1/Phase 2
Recruiting	`NCT03997643` - Preservation of Swallowing in Respected Oral Cavity Squamous Cell Carcinoma: Examining Radiation Volume Effects (PRESERVE): A Randomized Trial	Phase 2
Active, not recruiting	`NCT03170960` - Study of Cabozantinib in Combination With Atezolizumab to Subjects With Locally Advanced or Metastatic Solid Tumors	Phase 1/Phase 2
Recruiting	`NCT04700475` - Effect of Low Level Laser Therapy on Prevention of Radiotherapy Induced Xerostomia in Cancer Patients.	N/A
Withdrawn	`NCT04058145` - AMD3100 Plus Pembrolizumab in Immune Checkpoint Blockade Refractory Head and Neck Squamous Cell Carcinoma	Phase 2
Completed	`NCT02572869` - Functional and Aesthetic Outcomes After Mandible Reconstruction With Fibula Osteomyocutaneous Free Flaps
Active, not recruiting	`NCT04474470` - A Study to Evaluate NT219 Alone and in Combination With ERBITUX® (Cetuximab) in Adults With Advanced Solid Tumors and Head and Neck Cancer	Phase 1/Phase 2
Withdrawn	`NCT05073809` - Photoacoustic Imaging of Head and Neck Tumours
Active, not recruiting	`NCT04383210` - Study of Seribantumab in Adult Patients With NRG1 Gene Fusion Positive Advanced Solid Tumors	Phase 2
Active, not recruiting	`NCT03651570` - Randomized Controlled Trial of a E-intervention to Help Patients Newly Diagnosed With Cancer Cope Better: Pilot Study	N/A
Recruiting	`NCT04930432` - Study of MCLA-129, a Human Bispecific EGFR and cMet Antibody, in Patients With Advanced NSCLC and Other Solid Tumors	Phase 1/Phase 2
Recruiting	`NCT06016699` - Immunological Function After Radiation With Either Proton or Photon Therapy
Terminated	`NCT03843554` - Commensal Oral Microbiota in Head and Neck Cancer	N/A
Recruiting	`NCT05915572` - Mulligan Technique on Shoulder Dysfunction	N/A
Completed	`NCT05897983` - Tens and Rocabado Exercises on TMJ Dysfunction	N/A
Not yet recruiting	`NCT06289049` - Heavy Strength Training in Head and Neck Cancer Survivors	Phase 2
Withdrawn	`NCT05263648` - Virtual Reality Software to Reduce Stress in Cancer Patients	N/A
Withdrawn	`NCT03238638` - A Study of Epacadostat + Pembrolizumab in Head and Neck Cancer Patients, Who Failed Prior PD-1/PD-L1 Therapy	Phase 2

NCT number	NCT04313504
Study type	Interventional
Source	University of Cincinnati
Contact
Status	Active, not recruiting
Phase	Phase 2
Start date	November 4, 2020
Completion date	June 1, 2027

Study Evaluating the Efficacy of Niraparib and Dostarlimab (TSR-042) in Recurrent/Metastatic HNSCC

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms