Head and Neck Cancer Clinical Trial
Official title:
Gustatory Function Following Radiotherapy to the Head and Neck
The aim of this study is to assess the effect of RT or chemo-RT on chemosensory gustatory function in patients with HNC. By using detailed dosimetric data derived from the RT planning system, we will be able to calculate mean radiation doses to important structures including the anterior and posterior tongue, oral cavity, parotid and submandibular salivary glands, and correlate them with both qualitative and quantitative data for dysgeusia.
This study aims to collect data from patients with HNC undergoing RT or chemo-RT to correlate
quantitative chemosensory gustatory function with
- Detailed dosimetric data for critical structures relevant to perception of taste
- Fungiform papillae density (FPD)
- Use of concurrent platinum based therapy
- Patient reported taste loss using The Taste and Smell Survey (TSS) [14]
- Patient reported toxicity and overall QOL using University Washington Quality of Life
Revised Version 4 (UW-QOL v4) [15].
- Clinician reported acute and late toxicity using NCI Common Terminology Criteria for
Adverse Events Version 4.0 (CTCAE v4) [16] and Scale of Subjective Total Taste Acuity
(STTA) [17].
- Weight (as a surrogate of nutritional status).
This study hopes to demonstrate a dose dependent relationship for loss of taste and to
develop a dose constraint for preservation of taste. In turn this will serve as a platform
for further research to optimise the technical delivery of radiation either in the form of
optimised IMRT or through the use of intensity modulated proton therapy (IMPT).
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