Head and Neck Cancer Clinical Trial
Official title:
Evaluation of Polymorphisms and Mutations in Genes Postulated to Alter the Efficacy of Gefitinib in Samples From E1302
RATIONALE: Studying samples of blood and tissue from patients with cancer in the laboratory
may help doctors learn more about changes that occur in DNA and identify biomarkers related
to cancer. It may also help doctors predict how patients will respond to treatment.
PURPOSE: This laboratory study is looking at biomarkers in samples from patients with
recurrent or metastatic head and neck cancer treated on ECOG-E1302 trial.
OBJECTIVES:
- To evaluate the frequency of ATP-binding cassette, sub-family G (WHITE), member 2
(ABCG2), met proto-oncogene (hepatocyte growth factor receptor) (c-MET), and v-Ki-ras2
Kirsten rat sarcoma viral oncogene homolog (K-ras) polymorphisms or mutations in this
study population and the predictiveness of these polymorphisms on survival, time to
progression, response rate, and toxicities.
OUTLINE: Archived tumor tissue and peripheral blood mononuclear cells are analyzed for the
frequency of ABCG2, c-MET, and K-ras polymorphisms or mutations by polymerase chain reaction
(PCR). Results are then correlated with patients' clinical outcomes and toxicity.
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