Head and Neck Cancer Clinical Trial
Official title:
Irradiation Modulates the Pharmacokinetics of Anticancer Drugs for Head and Neck Cancer
The concurrent use of chemotherapy during radiation therapy (CCRT) is now the important
treatment stratagem for locally advanced head and neck cancer or nasopharyngeal cancer
(NPC). For these cases, 5-Fluorouracil (5-FU) and cisplatin (CDDP) are the most commonly
used agents of CCRT. It plays an important role to improve the treatment outcome and
increases the opportunities for organ preservation.
In the past, Radiotherapy (RT) was solely used as a local treatment and its effect was
estimated by local effect model. However, growing evidence shows that irradiation has direct
DNA damage-dependent effects as well as sending signals to neighboring cells. Recently, the
investigators reported that abdominal irradiation could significantly modulate the systemic
pharmacokinetics of 5-FU at 0.5 Gy, off-target area in clinical practice, and at 2 Gy, the
daily treatment dose for target treatment in an experimental rat model. Additionally, the
results from a clinical investigation showed that colorectal cancer patients with lower AUC
of 5-FU during adjuvant chemotherapy had lower disease-free survival. Taken together, these
lines of evidence support the importance and necessity to search for the mediators
responsible for the unexpected effect of local RT on systemic pharmacokinetics of
chemotherapeutic agents, such as 5-FU.
In the present study, the investigators examined whether the phenomena and mechanism of
RT-PK(pharmacokinetics) is a fact for different anticancer drugs and for different part in
human.
n/a
Observational Model: Case Control, Time Perspective: Prospective
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