Head and Neck Cancer Clinical Trial
Official title:
Induction Chemotherapy With Taxotere, Cisplatin and 5-Fluorouracil Followed by Concomitant Cetuximab and Radiation for Locoregionally Advanced Squamous Cell Cancer of the Head and Neck: A Phase II Trial
More than 50% of Head and Neck cancers are locally advanced at presentation. Although
surgery, in combination with other modalities like radiation therapy can achieve 40-50% five
year survival rates, resection in the head and neck region can leave patients with poor
functional and cosmetic outcomes.
Due to these concerns about quality of life after surgery, there has been a lot of interest
in non surgical alternatives of treatment. Various combinations of radiation, chemotherapy
and biologics has showed promising results. However, questions still remain about the ideal
combination treatment regimen.
Based on assimilation of data from multiple sources, our study tries to identify the role of
a potentially highly effective multi-modality regimen based on induction chemotherapy
(Cisplatin, Docetaxel and 5 Fluorouracil) followed by combination of a biologic agent,
Cetuximab, and radiation therapy.
Patients will be given two cycles of induction chemotherapy with Cisplatin, Docetaxel and Fluorouracil. This will be followed by six weeks of radiation therapy along with Cetuximab. Patients will get two more cycles of chemotherapy with the same agents after the completion of radiation therapy course. Patients will be watched very closely during the trial period, with close follow up of treatment responses and monitoring of any adverse effects. ;
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