Head and Neck Cancer Clinical Trial
Official title:
Detection of DNA Mutations in Head and Neck Squamous Cell Carcinoma
RATIONALE: DNA analysis of tumor tissue may help doctors predict how well patients will
respond to treatment.
PURPOSE: This research study is studying biomarkers in patients with head and neck cancer.
OBJECTIVES:
- To determine the mutation rates of HRAS and PIK3CA in patients with head and neck
squamous cell carcinoma (HNSCC) who were treated with cisplatin/placebo and
cisplatin/cetuximab on protocol ECOG-E5397.
- To determine the association between HRAS or PIK3CA mutation status and clinical
benefits (i.e., response, progression-free survival, and overall survival) in patients
treated with cisplatin/cetuximab compared with those receiving cisplatin/placebo on
protocol ECOG-E5397.
OUTLINE: DNA is isolated from one unstained slide per patient. The mutations in HRAS and
PIK3CA are determined using BEAMING technology.
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