Head and Neck Cancer Clinical Trial
Official title:
PTEN Determination in Squamous Cell Cancer of The Head and Neck Treated on E5397, A Randomized Phase III Trial of Cisplatin Plus Placebo Versus Cisplatin Plus C225 (Cetuximab) in Metastatic/Recurrent Head and Neck Cancer
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help
doctors predict how well patients will respond to treatment.
PURPOSE: This research study is studying biomarkers in patients with metastatic or recurrent
head and neck cancer treated with cisplatin and cetuximab on ECOG-E5397.
OBJECTIVES:
Primary
- Compare cetuximab activity, as reflected in response rate (RR), in PTEN-deficient and
PTEN-expressing cancers.
Secondary
- Examine RR, progression-free survival (PFS), and overall survival (OS) in
PTEN-deficient and PTEN-expressing cancers, by treatment arm.
OUTLINE: Tissue microarray slides collected earlier from ECOG-E5397 are immunostained with
PTEN antibody and analyzed with AQUA.
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